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Mashup Score: 1
ANCA-associated vasculitis displays autoimmune pathology involving inflammation of blood vessels. While ANCA autoantibodies have clinical utility, the underlying autoreactive T cells remain incompletely characterized in terms of function, T-cell receptor (TCR) repertoire and association with disease activity. The PR3 autoreactive CD4+T cells were enriched in cells expressing the G-protein coupled…
Source: Kidney InternationalCategories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 1
Potassium disorders are common in patients with kidney disease, particularly in patients with tubular disorders and low glomerular filtration rate. A multidisciplinary group of researchers and clinicians met in October 2018 to identify evidence and address controversies in potassium management. The issues discussed encompassed our latest understanding of the regulation of tubular potassium…
Source: Kidney InternationalCategories: Cardiologists, Latest HeadlinesTweet-
Potassium homeostasis and management of dyskalemia in #CKD #KDIGO https://t.co/ZDuBmETGOy
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Mashup Score: 0
Potassium disorders are common in patients with kidney disease, particularly in patients with tubular disorders and low glomerular filtration rate. A multidisciplinary group of researchers and clinicians met in October 2018 to identify evidence and address controversies in potassium management. The issues discussed encompassed our latest understanding of the regulation of tubular potassium…
Source: Kidney InternationalCategories: Hem/Oncs, Latest HeadlinesTweet-
Potassium homeostasis and management of dyskalemia in kidney diseases: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference - Kidney International https://t.co/btJcFpYbaq
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Mashup Score: 1
The novel nonsteroidal mineralocorticoid receptor antagonist finerenone has been shown to reduce the risk of kidney and cardiovascular outcomes in patients with type 2 diabetes and chronic kidney disease. In this issue of Kidney International, Bakris et al. present new data on the kidney efficacy of finerenone across subgroups of estimated glomerular filtration rate and urinary…
Source: Kidney InternationalCategories: Cardiologists, Latest HeadlinesTweet-
https://t.co/W2HiBbJR2J
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Mashup Score: 2Analysis from the FIDELITY study examined finerenone use and kidney outcomes in patients with chronic kidney disease and type 2 diabetes. - 2 year(s) ago
In FIDELITY, a pre-specified pooled analysis of the FIDELIO-DKD and FIGARO-DKD studies, finerenone was found to improve cardiorenal outcomes in patients with type 2 diabetes, a urine albumin-to creatinine ratio of 30–5000 mg/g, an estimated glomerular filtration rate (eGFR) of 25 ml/min/1.73 m2 or more and also receiving optimized renin–angiotensin system blockade treatment. This present analysis…
Source: Kidney InternationalCategories: Latest Headlines, NephrologyTweet-
Timely Finerenone renal analysis from FIDELITY (= FIDELIO + FIGARO) https://t.co/GVX2RpzPD9 in @Kidney_Int Of interest this subgroup analysis https://t.co/486DrWkAIb
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Mashup Score: 3A genomic deep field view of hypertension - 2 year(s) ago
Blood pressure is regulated by a complex neurohumoral system including the renin–angiotensin–aldosterone system, natriuretic peptides, endothelial pathways, the sympathetic nervous system, and the immune system. This review charts the evolution of our understanding of the genomic basis of hypertension at increasing resolution over the last five decades from monogenic causes to polygenic…
Source: Kidney InternationalCategories: Hem/Oncs, Latest HeadlinesTweet-
Thankful to Sandosh Padmanabhan @sandp27 @UofGSCMH for the opportunity to co-author this review in @Kidney_Int A Genomic Deep Field View of Hypertension https://t.co/0mdJR7zWAK #hypertension #Genomics @ucsdnephrology https://t.co/0H6A8CM5Tt
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Mashup Score: 4
The therapeutic potential of a novel, targeted-release formulation of oral budesonide (Nefecon) for the treatment of IgA nephropathy (IgAN) was first demonstrated by the phase 2b NEFIGAN trial. To verify these findings, the phase 3 NefigArd trial tested the efficacy and safety of nine months of treatment with Nefecon (16 mg/d) versus placebo in adult patients with primary IgAN at risk of…
Source: Kidney InternationalCategories: Latest Headlines, NephrologyTweet-
Published! (Months after being FDA approved) by @IgAN_JBarratt et al The phase 3A part of targeted release budesonide (called Nefecon) in IgA https://t.co/weF2dZ2Efg They included IgA with proteinuria > 1g and GFR 35 to 90 + max supported RASi see how that worked out: 1/ https://t.co/OK2cvElQvO
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Mashup Score: 1
People with diabetes and chronic kidney disease (CKD) are at high risk for kidney failure, atherosclerotic cardiovascular disease, heart failure, and premature mortality. Recent clinical trials support new approaches to treat diabetes and CKD. The 2022 American Diabetes Association (ADA) Standards of Medical Care in Diabetes and the Kidney Disease: Improving Global Outcomes (KDIGO) 2022 Clinical…
Source: Kidney InternationalCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @SeguraCardio: 📂https://t.co/YOGwvRE8AW
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Mashup Score: 0
People with diabetes and chronic kidney disease (CKD) are at high risk for kidney failure, atherosclerotic cardiovascular disease, heart failure, and premature mortality. Recent clinical trials support new approaches to treat diabetes and CKD. The 2022 American Diabetes Association (ADA) Standards of Medical Care in Diabetes and the Kidney Disease: Improving Global Outcomes (KDIGO) 2022 Clinical…
Source: Kidney InternationalCategories: Cardiologists, Latest HeadlinesTweet-
📂https://t.co/YOGwvRE8AW
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Mashup Score: 1Water-only pores and peritoneal dialysis - 2 year(s) ago
To the Editor: The excellent editorial by Michael Flessner1 implies that the idea of transcellular electrolyte-free water movement from peritoneal capillaries to peritoneal dialysis fluid during peritoneal dialysis, as a result of osmotic pressure-induced ultrafiltration, was not reported until the three-pore model of Rippe was published. Flessner states that, ‘Rippe was the first to realize the…
Source: Kidney InternationalCategories: Latest Headlines, NephrologyTweet-
Should be great! People often forget that a nephrologist studying peritoneal dialysis, Dr. Karl Nolph, made one of the first clinical demonstrations of water channels in the 1960s (for which he received some ridicule and struggled to get it published) https://t.co/trobxtoSW2 https://t.co/eW0K2nqmrc
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PR3 autoreactive CD4+T cells found in affected kidneys of 72 pts with PR3+ ANCA assoc vasculitis. These cytotoxic GPR56+CD4+T cells were significantly greater in those with inactive (vs active GPA), suggesting they may be affected by immunosuppression https://t.co/dHFhgnB8yE https://t.co/ZxV6INeCrU