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Mashup Score: 23
The comparative risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB) receiving tenofovir disoproxil fumarate (TDF) vs. entecavir (ETV) remains controversial. In this individual patient data (IPD) meta-analysis, we aimed to compare HCC risk between the two drugs and identify subgroups who may benefit more from one treatment than the other.
Source: Journal of HepatologyCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Inhibition of VEGF-B signaling prevents non-alcoholic fatty liver disease development by targeting lipolysis in the white adipose tissue - 1 year(s) ago
Hepatosteatosis is a hallmark of Non-alcoholic fatty liver disease (NAFLD), a common co-morbidity in Type 2 diabetes (T2DM). The pathogenesis of NAFLD is complex and involves the crosstalk between the liver and the white adipose tissues (WAT). Vascular Endothelial Growth Factor B (VEGF-B) has been described to control tissue lipid accumulation by regulating the transport properties of the…
Source: Journal of HepatologyCategories: Gastroenterology, Latest HeadlinesTweet-
#GastroEdPick Data from mouse models indicate that VEGFB antagonism reduced #NAFLD in diabetic mice by suppressing lipolysis in white adipose tissue. In biopsies from pts with NAFLD, VEGFB signalling was upregulated in white adipose tissue @JHepatology https://t.co/T6Ma6K3oAZ
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Mashup Score: 0Gut microbiota promote liver regeneration through hepatic membrane phospholipid biosynthesis - 1 year(s) ago
Hepatocyte growth and proliferation depends on membrane phospholipid biosynthesis. Short chain fatty acids (SCFA) generated by bacterial fermentation, delivered through the gut-liver axis, significantly contribute to lipid biosynthesis. We therefore hypothesized that dysbiotic insults like antibiotics treatment not only affect gut microbiota, but also impair hepatic lipid synthesis and liver…
Source: Journal of HepatologyCategories: Gastroenterology, Latest HeadlinesTweet-
#GastroEdPick Researchers have investigated the role of the #gutmicrobiota in hepatic membrane phospholipid biosynthesis and liver regeneration in mice @JHepatology https://t.co/i4sLsnCWxy
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Mashup Score: 4Esophageal varices: Stage-dependent treatment algorithm - 1 year(s) ago
The risk of developing variceal bleeding (and rebleeding) in patients with advanced chronic liver disease depends on the degree of portal hypertension, which can be assessed by measuring the hepatic venous pressure gradient (HVPG) at hepatic vein catheterization (normal ⩽5mmHg) [1]. Varices and other complications of portal hypertension do not develop until HVPG is of at least 10mmHg. These…
Source: Journal of HepatologyCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @ApoThera: Esophageal varices:Stage-dependent treatment algorithm https://t.co/zG0iD9BU6A #MedTwitter #MedEd #GITwitter #USMLE #healthca…
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Mashup Score: 44New diagnostic criteria and management of acute kidney injury - 1 year(s) ago
Traditionally, the diagnosis of renal dysfunction in cirrhosis is defined as a 50% increase in serum creatinine (SCr) with a final SCr of ⩾1.5mg/dl (133μmol/L) [1]. However, smaller rises in SCr have also been shown to have a negative prognostic impact in decompensated cirrhosis, especially in patients with infection [2]. Therefore, the International Club of Ascites, in line with other…
Source: Journal of HepatologyCategories: Cardiologists, Latest HeadlinesTweet-
RT @ApoThera: New diagnostic criteria and management of acute kidney injury https://t.co/WyNCWW3l75 #MedTwitter #MedEd #medstudents #medica…
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Mashup Score: 1Development and prognostic relevance of a histologic grading and staging system for alcohol-related liver disease - 1 year(s) ago
The SALVE Histopathology Group (SHG) developed and validated a grading and staging system for the clinical and full histological spectrum of alcohol-related liver disease (ALD) and evaluated its prognostic utility in a multinational cohort of 445 patients.
Source: Journal of HepatologyCategories: Gastroenterology, Latest HeadlinesTweet-
Diagnosis of alcohol associated #hepatitis ▪️ Minimal total bilirubin was lowered from 5mg/dL➡️3mg/dL ▪️ Transjugular liver biopsy is only recommended in patients w/factors that confound the diagnosis ▪️ SALVE grading & staging system for ALD: https://t.co/meaUnGJYUJ https://t.co/00jPKXUR9T
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Mashup Score: 15Treatment of NAFLD with diet, physical activity and exercise - 2 year(s) ago
Lifestyle intervention can be effective when treating non-alcoholic fatty liver diseases (NAFLD) patients. Weight loss decreases cardiovascular and diabetes risk and can also regress liver disease. Weight reductions of ⩾10% can induce a near universal non-alcoholic steatohepatitis resolution and fibrosis improvement by at least one stage. However, modest weight loss (>5%) can also produce…
Source: Journal of HepatologyCategories: Healthcare Professionals, Latest HeadlinesTweet-
RT @MichaelAlbertMD: Treat-to-target for NAFLD/NASH: 🔑 is ≥ 10% weight loss. https://t.co/9yp3clzwpU https://t.co/VTkAesYItT
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Mashup Score: 1
The burden of liver cancer varies across the world. Herein, we present updated estimates of the current global burden of liver cancer (incidence and mortality) and provide predictions of the number of cases/deaths to 2040.
Source: Journal of HepatologyCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @Valeriechew29: The number of new cases and deaths from liver cancer could rise by >55% by 2040! https://t.co/cPco7JbY6i
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Mashup Score: 0
The burden of liver cancer varies across the world. Herein, we present updated estimates of the current global burden of liver cancer (incidence and mortality) and provide predictions of the number of cases/deaths to 2040.
Source: Journal of HepatologyCategories: Hematologists1, Latest HeadlinesTweet-
Liver cancer cases and deaths projected to rise by more than 55% by 2040 https://t.co/2UY8l4e39D https://t.co/NsTXEauutx
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Mashup Score: 1
Adult-to-adult living donor liver transplantation (LDLT) offers an opportunity to decrease the liver transplant waitlist and reduce waitlist mortality. We sought to compare donor and recipient characteristics and post-transplant outcomes after LDLT in the US, the UK, and Canada.
Source: Journal of HepatologyCategories: Hematologists1, Latest HeadlinesTweet-
Long-term survival after living donor liver transplantation is excellent https://t.co/WKLgfv3ET7 https://t.co/VATkDQ86MF
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RT @giri_gutnliver: Tenofovir 💊 is superior to entecavir for 🔹Primary prevention of HCC & https://t.co/UY2SMrLqgY 🔹 Tertiary prevention of…