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Mashup Score: 69Treatment of NAFLD with diet, physical activity and exercise - 2 year(s) ago
Lifestyle intervention can be effective when treating non-alcoholic fatty liver diseases (NAFLD) patients. Weight loss decreases cardiovascular and diabetes risk and can also regress liver disease. Weight reductions of ⩾10% can induce a near universal non-alcoholic steatohepatitis resolution and fibrosis improvement by at least one stage. However, modest weight loss (>5%) can also produce…
Source: Journal of HepatologyCategories: Hematologists1, Latest HeadlinesTweet
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Mashup Score: 3Baveno VII – Renewing consensus in portal hypertension - 2 year(s) ago
To expand on the work of previous meetings, a virtual Baveno VII workshop was organised for October 2021. Among patients with compensated cirrhosis or compensated advanced chronic liver disease (cACLD – defined at the Baveno VI conference), the presence or absence of clinically significant portal hypertension (CSPH) is associated with differing outcomes, including risk of death, and different…
Source: Journal of HepatologyCategories: Gastroenterology, Latest HeadlinesTweet-
Reading the Baveno VII consensus document https://t.co/CwEncLCc8k "In patients presenting w/acute variceal bleeding, rapid removal of blood from the GI tract (lactulose PO/enemas) should be used to prevent hepatic encephalopathy" Do you routinely follow this? 👆 #livertwitter
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Mashup Score: 1Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL6 trans-signaling - 2 year(s) ago
Primary liver cancers include: Hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (CCA) and combined HCC-CCA tumors (cHCC-CCA). It has been suggested, but not unequivocally proven, that hepatic progenitor cells (HPCs) can contribute to hepatocarcinogenesis. We aimed to determine whether HPCs contribute to HCC, cHCC-CCA or both types of tumors.
Source: Journal of HepatologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL6 trans-signaling - Journal of Hepatology https://t.co/NMrMWFvILK
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Mashup Score: 0Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults - 2 year(s) ago
Hepatoblastoma (HB) and hepatocellular carcinoma (HCC) are the predominant types of liver cancers in children. HB and HCC outcomes and treatment options differ dramatically and most HBs have favorable outcomes following treatment by a combination of chemotherapy and resection. Risk-stratification using a combination of clinical, histological, and molecular parameters can improve therapy selection…
Source: Journal of HepatologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults - Journal of Hepatology https://t.co/0y2kvu8atf
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Mashup Score: 2Orthohepevirus C infection as an emerging cause of acute hepatitis in Spain: First report in Europe - 2 year(s) ago
Hepatitis E virus (HEV) was considered the only member of the Hepeviridae family with zoonotic potential. Nevertheless, this consideration has been reassessed owing to several reported cases of acute and chronic hepatitis linked to the Orthohepevirus C genus. Because the circulation of Orthohepevirus C in rodents has been described worldwide, the risk of zoonotic transmission is plausibly global.
Source: Journal of HepatologyCategories: Healthcare Professionals, Latest HeadlinesTweet-
RT @ironorehopper: @MackayIM Found the paper about Orthoherpesvirus C: https://t.co/2X4Tl87fIp
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Mashup Score: 1Racial and ethnic disparities in rifaximin use and subspecialty referrals for patients with hepatic encephalopathy in the United States - 2 year(s) ago
Rifaximin use in combination with lactulose is associated with a decreased risk of overt hepatic encephalopathy (HE). We sought to determine whether race and ethnicity was associated with rifaximin prescriptions.
Source: Journal of HepatologyCategories: Emergency Medicine, Latest HeadlinesTweet-
NEW: In @JHepatology we found that Asian, Black & Hispanic patients w. hepatic encephalopathy were ⬇️ likely to receive a Rifaximin prescription. Despite receiving ⬇️ prescription refills Black & Hispanic patients had ⬆️ out-of-spending. https://t.co/JAPZFmKoeB #Pharmacoequity https://t.co/5B8gslG6vK
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Mashup Score: 180BAVENO VII - RENEWING CONSENSUS IN PORTAL HYPERTENSION - 2 year(s) ago
Portal hypertension is a major consequence of cirrhosis and is responsible for its most severe complications, including ascites, bleeding from gastroesophageal varices and encephalopathy. The evaluation of diagnostic tools and the design and conduct of high-quality clinical trials for the treatment of portal hypertension and its complications have always been difficult. Awareness of these…
Source: Journal of HepatologyCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @drkeithsiau: Guidelines on variceal bleeding - fresh off the press from Baveno VII 🩸🆕 https://t.co/Jryanh4s1n https://t.co/hhCvPLam0X
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Mashup Score: 2Myeloid ikaros–SIRT1 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed mouse and human liver - 2 year(s) ago
Although Ikaros (IKZF1) is a well-established transcriptional regulator in leukocyte lymphopoiesis and differentiation, its role in myeloid innate immune responses remains unclear. Sirtuin 1 (SIRT1) is a histone/protein deacetylase involved in cellular senescence, inflammation, and stress resistance. However, whether SIRT1 signaling is essential in myeloid cell activation remains uncertain….
Source: Journal of HepatologyCategories: Gastroenterology, Latest HeadlinesTweet-
#GastroEdPick A new study describes how crosstalk between two transcriptional regulators (Ikaros and SIRT1) regulates hepatic inflammation + pyroptosis in ischaemic mouse + human livers @JHepatology https://t.co/cryXjhMwEW
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Mashup Score: 58Hepatopulmonary syndrome - 3 year(s) ago
Hepatopulmonary syndrome (HPS) is the most common cause of respiratory insufficiency in patients with chronic liver disease. It is characterised by a gas exchange abnormality caused by intrapulmonary vascular dilatations (IPVD) in patients with liver diseases. It occurs in 5–32% of liver transplant candidates.1 Abnormal oxygenation is defined by elevated alveolar-arterial oxygen gradient…
Source: Journal of HepatologyCategories: Healthcare Professionals, Latest HeadlinesTweet-
RT @drkeithsiau: Hepatopulmonary syndrome #LiverTwitter #4KMedEd (Via @JHepatology) https://t.co/dSNoGrWIyG https://t.co/rnGthKM0UO
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Mashup Score: 0
Alpha-1 antitrypsin deficiency (AATD) arises from mutations in the SERPINA1 gene encoding alpha-1 antitrypsin (AAT) that lead to AAT retention in the endoplasmic reticulum of hepatocytes, causing proteotoxic liver injury and loss-of-function lung disease. The homozygous Pi*Z mutation (Pi*ZZ genotype) is responsible for the majority of severe AATD cases and can precipitate both pediatric and adult…
Source: Journal of HepatologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Alpha-1 antitrypsin deficiency: a re-surfacing adult liver disorder - Journal of Hepatology https://t.co/8yT2GT4b6Y
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RT @drkeithsiau: Impact of weight loss on NAFLD #LiverTwitter #4KMedEd https://t.co/1KkikVanfm https://t.co/n5GqLWX1eo