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Mashup Score: 0Candidate Screening for Heart Failure With Preserved Ejection Fraction Clinic by Fib-4 Index From Subclinical Subjects - 1 year(s) ago
Heart failure with preserved ejection fraction (HFpEF), an emerging disease in recent years,1 has a poor prognosis similar to HF with reduced EF (HFrEF)2 and a higher rate of noncardiovascular events than HFrEF.3 Recognition of HFpEF at an early stage in a subclinical population during mass screenings, such as health check-up programs, for therapeutic intervention seems to be desirable because…
Source: Gastro Hep AdvancesCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0Causes and Outcomes of Medicolegal Proceedings Following Gastrointestinal Endoscopy in Canada - 1 year(s) ago
Endoscopic procedures are frequently performed in Canada but can be associated with potential complications and medicolegal implications. This study aimed to identify potential medicolegal cases in Canada relating to upper and lower endoscopies as well as advanced endoscopic procedures.
Source: Gastro Hep AdvancesCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 5
The integration of artificial intelligence (AI) into gastroenterology and hepatology (GI) will inevitably transform the practice of GI in the coming decade. While the application of AI in health care is not new, advancements are occurring rapidly, and the future landscape of AI is beginning to come into focus. From endoscopic assistance via computer vision technology to the predictive…
Source: Gastro Hep AdvancesCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0
Loss of bone morphogenetic protein (BMP) signaling in the stomach, achieved by transgenic expression of the BMP inhibitor noggin (H+/K+-Nog mice), causes parietal cell (PC) loss, spasmolytic polypeptide-expressing metaplasia, a marker of preneoplasia, and activation of cell proliferation. We examined if specific inhibition of BMP signaling in PCs leads to aberrations in epithelial homeostasis.
Source: Gastro Hep AdvancesCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 3The Expression of NHE8 in Liver and Its Role in Carbon Tetrachloride–Induced Liver Injury - 1 year(s) ago
Sodium-hydrogen exchanger 8 (NHE8) is expressed in array of tissues and has pleiotropic functions beyond simply exchanging sodium and hydrogen across cell membrane. This study investigates the expression pattern of liver NHE8 and its roles in carbon tetrachloride (CCl4)-induced liver injury.
Source: Gastro Hep AdvancesCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0It Is Time for a Simplified Approach to Hepatitis B Elimination - 1 year(s) ago
Hepatitis B virus (HBV) infection continues to threaten millions of lives across the globe, despite universal vaccination efforts. Current guidelines for screening, vaccination, and treatment are complex and have left too many people undiagnosed or improperly managed. Antiviral therapy has been shown to significantly reduce the incidence of liver-related complications, including liver cancer….
Source: Gastro Hep AdvancesCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0A Novel Pancreatic Cancer Mini-tumor Model to Study Desmoplasia and Myofibroblastic Cancer-Associated Fibroblast Differentiation - 1 year(s) ago
Pancreatic ductal adenocarcinoma (PDAC) patients often present with irresectable or metastasized disease, resulting in an overall 5-year survival rate of 11%.1 To improve current therapeutic modalities, modeling the full complexity of PDAC in a personalized fashion is essential. Organoid technology enables close-to-patient models but currently lacks the typical desmoplastic tumor…
Source: Gastro Hep AdvancesCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0
Paneth cells play a central role in intestinal innate immune response. These cells are localized at the base of small intestinal crypts of Lieberkuhn. The calcium-activated chloride channel TMEM16A and the phospholipid scramblase TMEM16F control intracellular Ca2+ signaling and exocytosis. We analyzed the role of TMEM16A and TMEM16F for Paneth cells secretion.
Source: Gastro Hep AdvancesCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0Epidermal Cyst in an Intrapancreatic Accessory Spleen - 1 year(s) ago
A 59-year-old asymptomatic woman with no disease history presented to our institution for investigation of a pancreatic tail mass. Hematological parameters were within normal ranges, including serum carcinoembryonic antigen levels and carboxyhydrate antigen 19-9. Computed tomography revealed a strongly enhanced solid peripheral mass with an intracystic component in the pancreatic tail (Figure A,…
Source: Gastro Hep AdvancesCategories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 1Malicious Mushrooms - 1 year(s) ago
Accidental ingestion of the toxic Death Cap mushroom, and others of the Amantina species, can occur due to their physical similarities with commonly edible fungi. Production of certain toxins which prevent protein synthesis can lead to fulminant organ failure and death. Although treatment is mostly supportive due to lack of specific antidote, early recognition can aid in meaningful recovery….
Source: Gastro Hep AdvancesCategories: Gastroenterology, Latest HeadlinesTweet
The Fib-4 index can be used to select appropriate candidates for a detailed examination of HFpEF in a subclinical population ➡️ https://t.co/zckFJQHFjY https://t.co/P5F51GG2HJ