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Mashup Score: 13
Tau accumulation in and neurodegeneration of locus coeruleus (LC) neurons is observed in Alzheimer’s disease (AD). We investigated whether tangle and neuronal density in the rostral and caudal LC is characterized by an asymmetric pattern in 77 autop
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Mashup Score: 10
Background: Alzheimer’s disease (AD) is a chronic neurodegenerative disease needing effective therapeutics urgently. Sildenafil, one of the approved phosphodiesterase-5 inhibitors, has been implicated as having potential effect in AD. Objective: To i
Source: content.iospress.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 7
Background: The possibility that Alzheimer’s disease and related dementias (ADRD) is a modern disease arises from the minimal mention of advanced cognitive decline by ancient Greeks and Romans, who were mainly concerned with the physical frailties of
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Mashup Score: 2Chronotropic Incompetence During Exercise Testing as a Marker of Autonomic Dysfunction in Individuals with Early Parkinson’s Disease - IOS Press - 4 month(s) ago
Background: An attenuated heart rate response to exercise, termed chronotropic incompetence, has been reported in Parkinson’s disease (PD). Chronotropic incompetence may be a marker of autonomic dysfunction and a cause of exercise intolerance in earl
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Mashup Score: 1
Pathologies characteristic of Alzheimer’s disease (i.e., hyperphosphorylated tau and amyloid-β (Aβ) plaques), cardiovascular disease, and limbic predominant TDP-43 encephalopathy (LATE) often co-exist in patients with Parkinson’s disease (PD), in add
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Mashup Score: 2Commentary on Novitas LCD - IOS Press - 5 month(s) ago
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Mashup Score: 16Exercise-Related Physical Activity Relates to Brain Volumes in 10,125 Individuals - IOS Press - 5 month(s) ago
Background: The potential neuroprotective effects of regular physical activity on brain structure are unclear, despite links between activity and reduced dementia risk. Objective: To investigate the relationships between regular moderate to vigorous
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Mashup Score: 19Pesticides and the Microbiome-Gut-Brain Axis: Convergent Pathways in the Pathogenesis of Parkinson’s Disease - IOS Press - 5 month(s) ago
The increasing global burden of Parkinson’s disease (PD), termed the PD pandemic, is exceeding expectations related purely to population aging and is likely driven in part by lifestyle changes and environmental factors. Pesticides are well recognized
Source: content.iospress.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 4Serotonin Degeneration and Amyloid-β Deposition in Mild Cognitive Impairment: Relationship to Cognitive Deficits - IOS Press - 5 month(s) ago
Background: Neuropathological and neuroimaging studies have demonstrated degeneration of the serotonin system in Alzheimer’s disease (AD). Neuroimaging studies have extended these observations to the preclinical stages of AD, mild cognitive impairmen
Source: content.iospress.comCategories: General Medicine News, NeurologyTweet
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Mashup Score: 4Serotonin Degeneration and Amyloid-β Deposition in Mild Cognitive Impairment: Relationship to Cognitive Deficits - IOS Press - 5 month(s) ago
Background: Neuropathological and neuroimaging studies have demonstrated degeneration of the serotonin system in Alzheimer’s disease (AD). Neuroimaging studies have extended these observations to the preclinical stages of AD, mild cognitive impairmen
Source: content.iospress.comCategories: General Medicine News, NeurologyTweet
What a great week for our blue spotters team!! @elise_beckers's work on asymmetry in #locuscoeruleus pathology in Alzheimer's Disease was published in @journal_ad! 🎉 https://t.co/3DSeb9EmwD