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Mashup Score: 3Role of sleep deprivation in immune-related disease risk and outcomes - Communications Biology - 2 year(s) ago
Garbarino et al review recent experimental and epidemiological developments regarding immune responses to sleep deprivation and consider the role for the sleep deprivation induced immune changes in increasing the risk for chronic diseases.
Source: Communications BiologyCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 5AMPK activator O304 improves metabolic and cardiac function, and exercise capacity in aged mice - Communications Biology - 2 year(s) ago
Ericsson et al. show in aged mice that the panAMPK activator O304 prevents and reverts age-associated hyperinsulinemia and insulin resistance, as well as improving cardiac function and exercise capacity. O304 thus functions as an exercise mimetic and could therefore have a similar therapeutic potential in aged humans and improve quality of life.
Source: Communications BiologyCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 11Location-dependent threat and associated neural abnormalities in clinical anxiety - Communications Biology - 3 year(s) ago
Suarez-Jimenez and colleagues use a shock and safe zone experiment with fMRI imaging to examine how pathological anxiety disorders are manifested in the brain. Their findings suggest that safe and dangerous zones within the experiment alter activation in different brain regions.
Source: Communications BiologyCategories: Latest Headlines, NeurologyTweet
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Mashup Score: 3Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics - Communications Biology - 3 year(s) ago
Huang et al demonstrate that glioblastoma cells upregulate axon guidance molecule Plexin-B2 to gain invasiveness and that Plexin-B2 promotes glioblastoma cell infiltration along axon fiber tracts in intracranial transplant models by modulating cellular biomechanics.
Source: Communications BiologyCategories: Latest Headlines, NeurologyTweet
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Mashup Score: 0EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1 - Communications Biology - 3 year(s) ago
Ando et al show in head and neck squamous cell carcinoma cells that EGFR activation leads to the phosphorylation of the Hippo pathway component, MOB1 to inhibit LATS1/2 function resulting in YAP/TAZ activation. Further, EGFR-targeting therapies suppress YAP/TAZ, and loss of LATS1/2-mediated YAP/TAZ activation confers therapy resistance, thus offering insights into potential drug resistance…
Source: Communications BiologyCategories: Latest Headlines, Oncologists2Tweet
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Mashup Score: 1
Elise Ishida et al. generate human monoclonal antibodies that can selectively recognize specific oligosaccharide epitopes of the polysaccharides arabinomannan and lipoarabinomannan, which are critical for M. tuberculosis pathogenesis. The authors demonstrate the utility of these antibodies in both diagnostic and laboratory settings, making them important tools for M. tuberculosis research.
Source: Communications BiologyCategories: Infectious Disease, Latest HeadlinesTweet
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Mashup Score: 19Trans-ethnic genome-wide association study of severe COVID-19 - Communications Biology - 3 year(s) ago
Chaolong Wang and colleagues report a large genome-wide association study for COVID-19 severity in Chinese individuals. By meta-analysis with European data, they identify 3 loci associated with severe disease that suggest key roles for the adaptive immune system and the ABO blood group system in development of severe COVID-19.
Source: Communications BiologyCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 24Tails stabilize landing of gliding geckos crashing head-first into tree trunks - Communications Biology - 3 year(s) ago
Siddall, Byrnes, Full, and Jusufi observe the function of the Asian flat-tailed gecko tail in gliding and landing on tree trunks in the field, complemented with mathematical and robotic models made of soft active materials. Altogether, their models show how geckos use an active tail reflex to brace the impact and reduce the risk of falling from landings on tree trunks.
Source: Communications BiologyCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 1Tumor microbiome contributes to an aggressive phenotype in the basal-like subtype of pancreatic cancer - Communications Biology - 3 year(s) ago
Guo, Zhang, Guo et al. investigate microbiome alterations in different molecular subtypes of PDAC and report that distinct signatures exist in basal-like tumours, characterized by an increase in certain bacteria, such as Acinetobacter, Pseudomonas and Sphingopyxis. The authors associate increases in these bacteria with increased inflammation and carcinogenic potential, as suggested by pathway…
Source: Communications BiologyCategories: Latest Headlines, Oncologists2Tweet
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Mashup Score: 36Trans-ethnic genome-wide association study of severe COVID-19 - Communications Biology - 3 year(s) ago
Chaolong Wang and colleagues report a large genome-wide association study for COVID-19 severity in Chinese individuals. By meta-analysis with European data, they identify 3 loci associated with severe disease that suggest key roles for the adaptive immune system and the ABO blood group system in development of severe COVID-19.
Source: Communications BiologyCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
RT @AndresFCardonaZ: Role of sleep deprivation in immune-related disease risk and outcomes - Perdidas! https://t.co/y0JxMao27K