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Mashup Score: 0Combination therapy with CAR T cells and oncolytic viruses: a new era in cancer immunotherapy - 3 year(s) ago
Chimeric antigen receptor (CAR) T-cell therapy is an encouraging and fast-growing platform used for the treatment of various types of tumors in human body. Despite the recent success of CAR T-cell therapy in hematologic malignancies, especially in B-cell lymphoma and acute lymphoblastic leukemia, the application of this treatment approach in solid tumors faced several obstacles resulted from the…
Source: Cancer Gene TherapyCategories: Infectious Disease, Latest HeadlinesTweet
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Mashup Score: 0Cancer Gene Therapy - 3 year(s) ago
Cancer Gene Therapy is the essential gene and cellular therapy resource for cancer researchers and clinicians, keeping readers up to date with the latest …
Source: Cancer Gene TherapyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
📢New QC checks introduced in CGT!📢 check them on our webpage: https://t.co/P1NPTwWcVQ
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Mashup Score: 0METTL3-mediated maturation of miR-126-5p promotes ovarian cancer progression via PTEN-mediated PI3K/Akt/mTOR pathway - 3 year(s) ago
Methyltransferase-like 3 (METTL3) functions as an RNA methyltransferase that controls the modification of N(6)-methyladenosine (m6A) to influence the biosynthesis, decay, and translation of mRNAs. This study aims to investigate the regulation of METTL3-mediated promotion of microRNA-126-5p (miR-126-5p) in the progression of ovarian cancer and to identify the mechanisms in relation to phosphatase…
Source: Cancer Gene TherapyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
March is #ovariancancer Awareness Month @OvarianCancerUK 🔬 Find many interesting papers on this topic on @cgtnature Let's start with the following one: https://t.co/9lKNI7aeKI
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Mashup Score: 0Cancer Gene Therapy - 3 year(s) ago
Cancer Gene Therapy is the essential gene and cellular therapy resource for cancer researchers and clinicians, keeping readers up to date with the latest …
Source: Cancer Gene TherapyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Come and have a look to our new journal homepage!🖥️ Hope you like our new design! https://t.co/P1NPTwWcVQ
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Mashup Score: 2The changing face of gastric cancer: epidemiologic trends and advances in novel therapies - 4 year(s) ago
Gastric cancer is an aggressive solid-tumor malignancy with poor prognosis. The epidemiologic face of gastric cancer is changing and further insight into its heterogenous immunohistopathologic nature is needed to develop personalized therapies for specific patient populations. In this review, we highlight changes in gastric cancer epidemiology with a special emphasis on racial and ethnic…
Source: Cancer Gene TherapyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
A new interesting review article discussing the changes in gastric cancer epidemiology and their implications in current clinical and preclinical treatment advances. Read now in @cgtnature! https://t.co/i2vQKfm6ht
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Mashup Score: 1Overexpressed sFRP3 exerts an inhibitory effect on hepatocellular carcinoma via inactivation of the Wnt/β-catenin signaling pathway - 4 year(s) ago
Hepatocellular carcinoma (HCC) is recognized as the most common malignancy of the liver in adults. Many human cancers have been associated with the oncogenic activation of the Wnt/β-catenin signaling pathway. The secreted frizzled-related proteins (sFRPs) function as negative regulators of the Wnt signaling and have important implications in carcinogenesis. This study aims to investigate the…
Source: Cancer Gene TherapyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Out today! A new interesting paper investigating the possible regulatory effects of sFRP3 on the Wnt/β-catenin signaling pathway and their interactions in HCC occurrence! Read it in @cgtnature https://t.co/my8xMDkTzA
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Mashup Score: 1LINC00671 suppresses cell proliferation and metastasis in pancreatic cancer by inhibiting AKT and ERK signaling pathway - 4 year(s) ago
Long noncoding RNAs (lncRNAs) represent an emerging field of tumor biology, playing essential roles in cancer cell proliferation, invasion, and metastasis. However, the overall functional and clinical significance of most lncRNAs in pancreatic cancer is not thoroughly understood. Here, we described most of the lncRNAs with aberrant expression patterns in pancreatic cancer as detected by…
Source: Cancer Gene TherapyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
New interesting papers on the emerging role of long noncoding RNAs and circular RNAs in #Cancers Read now in #cgtnature https://t.co/h0rG8Jfs6O
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Mashup Score: 0circRACGAP1 promotes non-small cell lung cancer proliferation by regulating miR-144-5p/CDKL1 signaling pathway - 4 year(s) ago
Circular RNAs (circRNAs) are involved in the regulation of many pathophysiological processes as non-coding RNAs. This study focuses on the role of circRACGAP1 in the development of non-small cell lung cancer (NSCLC). Expression patterns of circRACGAP1 and miR-144-5p in NSCLC tissues and cell lines were quantified by qRT-PCR analysis. Then, the function of circRACGAP1 on cell proliferation and…
Source: Cancer Gene TherapyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
https://t.co/gm2U1yDrHl
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Mashup Score: 0Expression pattern of m6A regulators is significantly correlated with malignancy and antitumor immune response of breast cancer - 4 year(s) ago
More than 24 regulators have been revealed to dynamically participant in N6-methyladenosine (m6A) RNA methylation, and play critical roles in tumorigenesis and development of cancers. However, their functional roles have not been comprehensively clarified in breast cancer. Here we systematically analyzed the RNA sequencing data of 24 main m6A RNA methylation regulators in 775 breast cancer…
Source: Cancer Gene TherapyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Now out in @cgtnature https://t.co/JR6eWdJrRe
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Mashup Score: 0EPHA5 mutation predicts the durable clinical benefit of immune checkpoint inhibitors in patients with lung adenocarcinoma - 4 year(s) ago
Immune checkpoint inhibitor (ICI) therapy has shown remarkable clinical benefit in lung adenocarcinoma (LUAD) patients. Genomic mutations may be applicable to predict the response to ICIs. Eph receptor A5 (EPHA5) is frequently mutated in breast cancer, lung cancer, and other tumors; however, its association with outcome in patients who receive immunotherapy remains unknown. In this study, we…
Source: Cancer Gene TherapyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
https://t.co/QquIsYg5Xt
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A new era in cancer #immunotherapy? The authors review the outcomes resulted from the combination of CAR T-cell immunotherapy and oncolytic #virotherapy for the treatment of solid cancers. https://t.co/0STzwVCmAL https://t.co/It6SBPRNtL