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Mashup Score: 0
OPCML is a highly conserved glycosyl phosphatidylinositol (GPI)-anchored protein belonging to the IgLON family of cell adhesion molecules. OPCML functions as a tumor suppressor and is silenced in over 80% of ovarian cancers by loss of heterozygosity and by epigenetic mechanisms. OPCML inactivation is also observed in many other cancers suggesting a conservation of tumor suppressor function….
Source: Cancer Gene TherapyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0LIPG: an inflammation and cancer modulator - 4 year(s) ago
Endothelial lipase (LIPG/EL) performs fundamental and vital roles in the human body, including cell composition, cytokine expression, and energy provision. Since LIPG predominantly functions as a phospholipase as well as presents low levels of triglyceride lipase activity, it plays an essential role in lipoprotein metabolism, and involves in the metabolic syndromes such as inflammatory response…
Source: Cancer Gene TherapyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
New interesting review on endothelial lipase roles in inflammation and cancer. Read it in @cgtnature #cancerresearch https://t.co/KtGfVFt4Jd
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Mashup Score: 0
Cancer stem cells (CSCs) are responsible for tumor initiation, relapse, and metastasis. Thus, residual CSCs after chemotherapy may result in poor prognosis for nasopharyngeal carcinoma (NPC). Emerging evidence suggests that differentially expressed microRNAs (miRNAs) regulate genes that carry out important functions in CSCs. Here we investigate the interaction of microRNA-873 (miR-873) with the…
Source: Cancer Gene TherapyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Have a look to the newly published papers! https://t.co/yccu2clFi6
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Mashup Score: 1Apatinib prevents natural killer cell dysfunction to enhance the efficacy of anti-PD-1 immunotherapy in hepatocellular carcinoma - 4 year(s) ago
Apatinib, a selective vascular endothelial growth factor receptor 2-tyrosine kinase inhibitor, has demonstrated activity against a wide range of solid tumors, including advanced hepatocellular carcinoma (HCC). Preclinical and preliminary clinical results have confirmed the synergistic antitumor effects of apatinib in combination with anti-programmed death-1 (PD-1) blockade. However, the…
Source: Cancer Gene TherapyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
https://t.co/3hjXkFZU5h
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Mashup Score: 0Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms - 4 year(s) ago
Cancer immunotherapy has revolutionised cancer treatment, with immune checkpoint blockade (ICB) therapy and adoptive cell therapy (ACT) increasingly becoming standard of care across a growing number of cancer indications. While the majority of cancer immunotherapies focus on harnessing the anti-tumour CD8+ cytotoxic T cell response, the potential role of CD4+ ‘helper’ T cells has largely remained…
Source: Cancer Gene TherapyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Immunotherapy has revolutionised cancer treatment 💊 An interesting update on the role of CD4+ T cells in cancer immunotherapy is now available in @cgtnature https://t.co/CxAmBaGsSZ
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Mashup Score: 0AKT and JUN are differentially activated in mesenchymal stem cells after infection with human and canine oncolytic adenoviruses - 4 year(s) ago
There is increasing evidence about the use of oncolytic adenoviruses (Ads) as promising immunotherapy agents. We have previously demonstrated the clinical efficiency of mesenchymal stem cells (MSCs) infected with oncolytic Ads as an antitumoral immunotherapy (called Celyvir) in human and canine patients, using ICOVIR-5 or ICOCAV17 as human and canine oncolytic Ads, respectively. Considering the…
Source: Cancer Gene TherapyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
👉 New updates on the use of oncolytic adenoviruses as promising @immunotherapy agents https://t.co/DV5MTxb8FI
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Mashup Score: 0RHPN1-AS1 promotes cell proliferation and migration via miR-665/Akt3 in ovarian cancer - 4 year(s) ago
Recent efforts have revealed that long non-coding RNAs exert crucial roles in cancer initiation and progression. RHPN1-AS1 is a 2030 bp transcript from human chromosome 8q24, and involved in tumorigenesis in uveal melanoma and non-small cell lung cancer, but it remains unknown in ovarian cancer. This study focused on the role of RHPN1-AS1 in ovarian cancer and found that RHPN1-AS1 was…
Source: Cancer Gene TherapyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Many new interesting papers are out today! Read them now in @cgtnature 👉 New insights in the role of the long coding RNA RHPN1-AS1 in @ovariancancer https://t.co/uZCBx1eWWk
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Mashup Score: 0Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death - 4 year(s) ago
Ferroptosis has become a topic of rapidly growing interest in recent years, and has possible therapy implications in cancer therapy. Although excessive autophagy may contribute to ferroptosis, its underlying molecular mechanism remains largely unknown. Here, we provide novel evidence that the interplay between the signals of mechanistic target of rapamycin kinase (MTOR) and glutathione peroxidase…
Source: Cancer Gene TherapyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
👉 Novel evidence about the interplay between MTOR and GPX4 in modulating autophagy-dependent ferroptosis in human pancreatic cancer cells https://t.co/oWkNwKYyIn
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Mashup Score: 0
Recent studies have suggested that lincRNA-ROR is involved in the tumorigenesis of different types of cancers. However, the role of lincRNA-ROR in retinoblastoma has not been determined. We investigated lincRNA-ROR levels in 58 retinoblastoma and adjacent non-tumor tissues by quantitative reverse transcription PCR. Recurrence-free survival was analyzed using Cox regression analyses. Cell…
Source: Cancer Gene TherapyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
New interesting paper about the role of lincRNA-ROR in @retinoblastoma. Read it in @cgtnature 👇 https://t.co/muIen4zCFH
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Mashup Score: 0Genetically engineered mesenchymal stem cells: targeted delivery of immunomodulatory agents for tumor eradication - 4 year(s) ago
Cancer immunotherapy emerged as a novel therapeutic option that employs enhanced or amended native immune system to create a robust response against malignant cells. The systemic therapies with immune-stimulating cytokines have resulted in substantial dose-limiting toxicities. Targeted cytokine immunotherapy is being explored to overcome the heterogeneity of malignant cells and tumor cell defense…
Source: Cancer Gene TherapyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
New paper is out! Novel interesting approach for the delivery of immunomodulatory agents for tumor eradication! @immunotherapy @cancerresearch @cgtnature https://t.co/ayqfj8x5BJ
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Out now in @cgtnature ! A new interesting review about the emerging roles of OPCML in #Cancers! https://t.co/cFgL0zhyuB