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Mashup Score: 0Clinicopathologic analysis of microscopic tumor extension in glioma for external beam radiotherapy planning - BMC Medicine - 2 year(s) ago
Background There is no consensus regarding the clinical target volume (CTV) margins in radiotherapy for glioma. In this study, we aimed to perform a complete macropathologic analysis examining microscopic tumor extension (ME) to more accurately define the CTV in glioma. Methods Thirty-eight supra-total resection specimens of glioma patients were examined on histologic sections. The ME distance,…
Source: BMC MedicineCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 0
Background Model-based estimates of measles burden and the impact of measles-containing vaccine (MCV) are crucial for global health priority setting. Recently, evidence from systematic reviews and database analyses have improved our understanding of key determinants of MCV impact. We explore how representations of these determinants affect model-based estimation of vaccination impact in ten…
Source: BMC MedicineCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
A DynaMICE modelling study into ten high-burden countries studying the effect of evidence updates on key determinants of #measles #vaccination impact Read it here: https://t.co/klyyBi9jti https://t.co/qtP6h7UWMd
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Mashup Score: 3IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis - BMC Medicine - 3 year(s) ago
Background Combination antiretroviral treatment (cART) cannot eradicate HIV-1 from the body due to the establishment of persisting viral reservoirs which are not affected by therapy and reinitiate new rounds of HIV-1 replication after treatment interruption. These HIV-1 reservoirs mainly comprise long-lived resting memory CD4+ T cells and are established early after infection. There is a high…
Source: BMC MedicineCategories: Infectious Disease, Latest HeadlinesTweet-
🧬A genome-wide association analysis conducted by Dr. Yang Li and Andre van der Ven's team at @researchumcg and @radboudumc found that IRF7 and RNH1 are modifying factors of #HIV-1 reservoirs. https://t.co/k1anv6Dugs https://t.co/DXctSsBYaz
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Mashup Score: 0Prediction of P-tau/Aβ42 in the cerebrospinal fluid with blood microRNAs in Alzheimer’s disease - BMC Medicine - 3 year(s) ago
Background The most common biomarkers of Alzheimer’s disease (AD) are amyloid β (Aβ) and tau, detected in cerebrospinal fluid (CSF) or with positron emission tomography imaging. However, these procedures are invasive and expensive, which hamper their availability to the general population. Here, we report a panel of microRNAs (miRNAs) in serum that can predict P-tau/Aβ42 in CSF and readily…
Source: BMC MedicineCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Study investigates P-tau/Aβ42 as prediction markers in the #CSF with blood #microRNA in #Alzheimers disease Read it here: https://t.co/Insx2l1PDT https://t.co/8rPTKnwFQ6
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Mashup Score: 0
Background Late stillbirth continues to affect 3–4/1000 pregnancies in high-resource settings, with even higher rates in low-resource settings. Reduced foetal movements are frequently reported by women prior to foetal death, but there remains a poor understanding of the reasons and how to deal with this symptom clinically, particularly during the preterm phase of gestation. We aimed to determine…
Source: BMC MedicineCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
An IPD meta-analysis investigates the association between #maternal perception of #foetal movements and stillbirth Read it here: https://t.co/gnEehYN5NS https://t.co/dmhumiafXT
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Mashup Score: 2
Background Multi-omics studies have shown a high and lack of common driver mutations in most thymomas (TH) and thymic carcinomas (TC) that hamper the development of novel treatment approaches. However, deregulation of apoptosis has been proposed as a common hallmark of TH and TC. BH3 profiling can be utilized to study the readiness of living cancer cells to undergo apoptosis and their dependency…
Source: BMC MedicineCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Functional #apoptosis profiling identifies MCL-1 and BCL-xL as prognostic #markers and therapeutic targets in advanced #thymic carcinomas and #thymomas Read it here: https://t.co/ozGwasCOWd https://t.co/JQlo1Msehd
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Mashup Score: 0IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis - BMC Medicine - 3 year(s) ago
Background Combination antiretroviral treatment (cART) cannot eradicate HIV-1 from the body due to the establishment of persisting viral reservoirs which are not affected by therapy and reinitiate new rounds of HIV-1 replication after treatment interruption. These HIV-1 reservoirs mainly comprise long-lived resting memory CD4+ T cells and are established early after infection. There is a high…
Source: BMC MedicineCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
A #GWAS analysis identifies IRF7 and RNH1 as modifying factors of #HIV-1 reservoirs Read it here: https://t.co/erz6V31HJS https://t.co/WB2W1du5qU
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Mashup Score: 1
Background The BNT162b2 mRNA vaccine has been shown to be effective at preventing serious COVID-19 events in clinical trials. There is less evidence on effectiveness in real-world settings, especially for older people. Here, we aimed to estimate vaccine effectiveness in the context of the rapid NHS mass-vaccination programme in England, exploiting age-based vaccination eligibility thresholds to…
Source: BMC MedicineCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
A study published in #BMCMedicine reports that the Pfizer-BioNTech vaccine is effective at reducing COVID-19 hospitalisations and infections among older adults. The vaccination of older adults in England also reduced the burden of COVID-19. https://t.co/6qpUibp2Yw
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Mashup Score: 0Depression sum-scores don’t add up: why analyzing specific depression symptoms is essential - BMC Medicine - 3 year(s) ago
Most measures of depression severity are based on the number of reported symptoms, and threshold scores are often used to classify individuals as healthy or depressed. This method – and research results based on it – are valid if depression is a single condition, and all symptoms are equally good severity indicators. Here, we review a host of studies documenting that specific depressive symptoms…
Source: BMC MedicineCategories: Healthcare Professionals, Latest HeadlinesTweet-
Depression sum-scores don’t add up: why analyzing specific depression symptoms is essential https://t.co/cRSplmIZKr via @EikoFried et al @SameiHuda
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Mashup Score: 0
Background Adolescents experience a multitude of vulnerabilities which need to be addressed in order to achieve the Sustainable Development Goals (SDGs). In sub-Saharan Africa, adolescents experience high burden of HIV, violence exposure, poverty, and poor mental and physical health. This study aimed to identify interventions and circumstances associated with three or more targets…
Source: BMC MedicineCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Identifying interventions associated with Sustainable Development Goals (#SDGs) outcomes relating to #HIV infected adolescents. Read it here: https://t.co/KSpcKWGfOg https://t.co/XkNdtaetgi
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Clinicopathologic analysis of #microscopic #tumor extension in #glioma for planning external beam #radiotherapy Read it here: https://t.co/Ff8hWyn1eE https://t.co/CxZvlPFV5n