Currently very little is known about how our immune system responds to SARS-CoV-2 infection. Here the authors generate a SARS-CoV-2 proteome microarray for profiling of IgG and IgM responses to COVID-19 in patients and find significant responses to ORF9b and NSP5, as well as the S1 and N proteins.
BACKGROUND AND OBJECTIVES:. Respiratory viral infections increase risk of asthma in infants and children. Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus…
This review focuses on three major aspects of oncoviruses’ role in cancer development. To begin, we discuss their geographic distribution, revealing that seven oncoviruses cause…
Nature Microbiology – IFITM1 can compete with EBV glycoproteins for EphA2 binding and prevent virus entry into epithelial cells, in vitro and in vivo. YTHDF3…
Nature Communications – HIV exposed but uninfected infants may face an increased risk of serious infection and mortality. In this work, the authors utilise a…
Abstract. It has been proposed that coronavirus nsp15 mediates evasion of host cell double-stranded (ds) RNA sensors via its uracil-specific endoribonuclea
C-type lectin receptors (CLRs) comprise a vast family of proteins, several of which play key roles in the immune system. In this article, Reis e…
Non-structural protein 2 (nsp2) exists in all coronaviruses (CoVs), while its primary function in viral pathogenicity, is largely unclear. One such enteric CoV, porcine epidemic…
Findings show a newly created drug can prevent runaway inflammation while still allowing the immune system to handle the virus, even when given late into…
Nature Immunology – Here the authors identify the transcription factor MEF2C as essential for human NK cell function and viral immunity in mice and humans.…
