CD8+ T cells integrate signals from the local microenvironment to establish tissue residency, but which factors are involved and how remain unresolved. Obers et al. highlight the role of retinoic acid (RA) in promoting TRM cell formation across multiple tissues and supporting intestinal TRM cell maintenance by restricting their migration to draining lymph nodes.
Lactylation, a recently identified post-translational modification, has initially been linked to gene transcription regulation through epigenetic mechanisms. However, its role in tumorigenesis—whether as a major…
Together with structural analyses, a cell-free system for transcription-coupled nucleotide excision repair (TC-NER) shows that STK19 is an integral component of the TC-NER complex that…
Reflecting on his career journey and the molecular basis of life with Dr. Zhu.
The gut microbiota has been implicated in the development of obesity, and especially early life has been proposed to be important. Poulsen et al. followed 700…
Selenium is crucial for cell function and ferroptosis prevention. Chen et al. discovered that peroxiredoxin 6 (PRDX6) binds directly to selenide and promotes its efficient use,…
Ito et al. highlight peroxiredoxin 6 (PRDX6) as a critical regulator of ferroptosis. As a selenium-acceptor protein, PRDX6 aids in intracellular selenium utilization for efficient selenoprotein…
Th17 cells can either maintain homeostatic tissue functions or drive damaging tissue inflammation. IL-23 is the key driver of the pro-inflammatory state, but the mechanisms…
STK19 functions in transcription-coupled DNA repair, aiding the clearance of RNAPII and advancing the repair process by positioning the ATPase subunits of TFIIH onto DNA.
Pathogenic protein aggregation drives Alzheimer’s disease, but how it is initiated remains unclear. By generating a APOE-HaloTag knockin mouse model and optimizing APOE purification techniques, Kaji…
Despite aging being one of the strongest risk factors for cancer, little is known about the biological mechanisms that promote tumor initiation. In this issue…
