Precision off-the-shelf natural killer cell therapies for oncology with logic-gated gene circuits
Treating acute myeloid leukemia with conventional, single-target CAR cell therapies is challenging due to tumor heterogeneity and because tumor antigens are found on hematopoietic stem cells. Frankel et al. design logic-gated CAR-natural killer cells that simultaneously detect three antigens on prospective target cells to safely decide whether to kill them.