Selenium is crucial for cell function and ferroptosis prevention. Chen et al. discovered that peroxiredoxin 6 (PRDX6) binds directly to selenide and promotes its efficient use, enhancing selenoprotein translation. This discovery offers further possibilities for therapeutic exploitation, as higher PRDX6 expression correlates with the aggressive nature of certain neuroblastoma subtypes.
This study identifies a small molecule (TAC) that restores physiological levels of TERT throughout aged tissues, resulting in the rejuvenation of multiple tissues. Specifically, TAC…
RFK Jr.’s ‘Make America Healthy Again’ agenda focuses on overhauling health care and food to combat chronic disease
This cohort study evaluates the survival outcomes of currently smoking patients with cancer who entered into a smoking cessation treatment program based on the time…
Join Dr. Lisa Zhang from Massachusetts General Hospital as she interviews leading pathology experts, Dr. Sarah Dry, Chair of Pathology at UCLA, and Dr. Laura…
Background Hospital at Home (HaH) is a growing care model requiring significant investments. Critical to starting a program is estimating census and enrollments. The objective…
Lactylation, a recently identified post-translational modification, has initially been linked to gene transcription regulation through epigenetic mechanisms. However, its role in tumorigenesis—whether as a major…
This cohort study examines the prevalence of and factors associated with financial hardship among US adults aged 40 years or younger treated for breast cancer.
This cross-sectional study examines the content and quality of information about urinary tract infections and asymptomatic bacteriuria on publicly available websites.
Together with structural analyses, a cell-free system for transcription-coupled nucleotide excision repair (TC-NER) shows that STK19 is an integral component of the TC-NER complex that…
