Photos: Kids celebrate the new year at noon in Iowa City
More than 350 on hand for balloon drop at Iowa City Public Library
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NEK7 phosphorylation amplifies NLRP3 inflammasome activation downstream of potassium efflux and gasdermin D
NEK7 phosphorylation amplifies NLRP3 activation.
Structures of ATP-binding cassette transporter ABCC1 reveal the molecular basis of cyclic dinucleotide cGAMP export
ABCC1 mediates the export of cGAMP, but the underlying molecular mechanism of cGAMP recognition and export is not clear. Here, Shinde et al. show that human…
Guidance on Food Allergen Labeling (Edition 5)
The guidance explains, using a question and answer format, FDA’s current thinking on a number of issues related to the regulation of food allergens, including…
Endogenous thymic regeneration: restoring T cell production following injury
Nature Reviews Immunology – This Review discusses recent advances in our understanding of the biology of endogenous tissue regeneration in the thymus, highlighting the clinical…
Late effects following hematopoietic cell transplantation for severe combined immunodeficiency: critical factors and therapeutic options – PubMed
Ongoing research efforts are needed to better describe CLE in survivors, to develop prospective clinical trials aimed at mitigating these CLE, and developing genotype-based approaches…
Novel Inherited N-terminus TAP1 Variants and Severe Clinical Manifestations- Are Genotype-Phenotype Correlations Emerging? – PubMed
Major histocompatibility complex class I deficiency results from deleterious biallelic variants in TAP1, TAP2, TAPBP, and B2M genes. Only a few patients with variant-curated TAP1…
Genome characteristics at the borders
Nature Reviews Molecular Cell Biology – Marina Lusic recounts seminal papers that showed that nuclear pore complexes and association with the nuclear lamina can shape…
Suppression of thrombospondin-1–mediated inflammaging prolongs hematopoietic health span
Deletion of thrombospondin-1 prevents inflammaging and preserves blood stem cell fitness during aging.