Pancreatic β cell interleukin-22 receptor subunit alpha 1 deficiency impairs β cell function in type 2 diabetes via cytochrome b5 reductase 3
β Cell dysfunction is a hallmark of type 2 diabetes. Yu et al. demonstrate the crucial role of IL-22RA1 in preserving β cell function and glucose homeostasis under metabolic stress. Mechanistically, β cell IL-22RA1 acts on the STAT3/c-Jun/CYB5R3 axis to promote mitochondrial function and the expression of β cell identity genes.