Animal-based models mimicking human physiological responses against SARS-CoV-2 could advance ongoing research for designing appropriate anti-SARS-CoV-2 strat…
Alveolar septation increases gas-exchange surface area and requires coordinated cytoskeletal rearrangement in lung fibroblasts (LFs) to balance the demands of contraction and cell migration. We…
Secondary septa formation is a crucial process in the development of pulmonary alveoli, the small air sacs in the lungs where gas exchange occurs. During…
“.” American Journal of Respiratory Cell and Molecular Biology, 70(4), pp. 322–325 Supported by National Institutes of Health grants R01 AT011676 (X.S.), 1R01 HL160019-01 (X.S.),…
Mammalian lungs are directly exposed to environmental pathogens and toxins and have evolved complex defense mechanisms, including the mucociliary escalator and secretion of antimicrobial peptides…
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disease caused by an aberrant repair of injured alveolar epithelial cells. The maintenance of the alveolar…
Alveolar type 2 (AT2) cells are progenitors of alveolar type I cells and play a critical role in the regeneration of the alveoli after injury.…
BCL-2 family members are known to be implicated in survival in numerous biological settings. Here, we provide evidence that in injury and repair processes in…
Host: Matthew R. Moll, MD, Brigham and Women’s HospitalGuest Speakers: David C. Christiani, MD, MPH, MS, ATSF, Mass General Hospital; and Mark M. Wurfel, MD,…
