Alveolar Epithelial Cell Dysfunction in Idiopathic Pulmonary Fibrosis Linked to Lipid Alterations: Therapeutic Implications
Alveolar type 2 (AT2) cells are progenitors of alveolar type I cells and play a critical role in the regeneration of the alveoli after injury. AT2 epithelial cell injury, exhaustion, aberrant repair, and insufficient reepithelialization disturb homeostasis and contribute to structural damage in idiopathic pulmonary fibrosis (IPF) (1). The mechanism of alveolar reepithelialization is still elusive, and treatments targeting AT2 cell proliferation and differentiation have yet to be developed (2). Apart from