Identifying key randomised clinical trials that could transform clinical care and public health
Clinical trials have been pivotal to the improvements in public health and clinical care, leading to many millions of additional years of healthy life globally. Some examples of disease areas in which outcomes have improved include primary and secondary prevention of cardiovascular disease, breast cancer, some forms of leukaemia, and HIV treatment and prevention. In all of these disease domains, clinical practitioners have embraced the centrality of evidence from clinical trials and large-scale randomised clinical trial (RCT) collaborations have been implemented in partnership with patients, health systems, industry, and other partners.
