Hippocampal astrocytes induce sex-dimorphic effects on memory
Meadows et al. identify sex-dependent effects of glial receptors on neurocognitive function. Changes in mGluR3 levels or activation of Gi/o-coupled or Gs-coupled receptors in adult hippocampal astrocytes had divergent effects on memory across sexes. These results suggest that astrocytic receptors promote sex differences in behavior.