Calvarial bones safeguard the brain and are interconnected by immovable joints termed sutures, which function as growth centers for skull morphogenesis and stem cell niches. Recent years have witnessed paradigm shifts in this field, highlighting the essential roles of calvarial stem cells (CSCs), sutures, and surrounding structures in neuroimmune crosstalk and neurocognitive restoration.
Nature Chemical Biology – A compound screen using zebrafish identified carbonic anhydrase (CA) as a modulator of tau toxicity. CA inhibition abrogates lysosomal acidification and…
In this issue of Cancer Cell, MacFawn et al. reveal that tertiary lymphoid structures (TLSs) in high-grade serous ovarian cancer (HGSOC) vary significantly by anatomical site.…
Pyroptosis is an immunogenic cell death that can promote antitumor immunity. This study identified a small molecule agonist of GSDMD that induced GSDMD pore formation…
Wrapping up #BreastCancerAwarenessMonth with an important conversation on @9news: Inflammatory breast cancer—a type that may not be caught on mammograms. Kno…
Many magic tricks rely solely on vision, but there are few, if any, that rely on auditory perception alone. Here, we question why this is…
During carcinoma metastasis, malignant progenitors undergo a TGF-β-dependent EMT associated with fibroblast activation and extracellular matrix remodeling in the tumor microenvironment. RAS-activated RREB1 primes enhancers…
Combinatorial immunotherapy may improve the efficacy of neoadjuvant checkpoint inhibitors in locoregionally advanced melanoma. In this issue of Cancer Cell, Davar and colleagues report a…
The burgeoning field is still grappling with fundamental problems, from getting access to data to defining ‘misinformation’ in the first place
NewVue and Enlitic plan to partner on developing AI algorithms that automate data standardization.
Proper cell fate acquisition in time and space determines tissue architecture, but how tissue architecture influences cell fate is less clear. Lancaster and colleagues investigated…
