G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s disease pathogenesis
Stykel et al. show that G6PD missense mutations increase the risk of PD diagnosis and that α-syn accumulation leads to G6PD dysfunction and deposition into Lewy bodies. This leads to loss of redox homeostasis and dopamine oxidation that can be rescued pharmacologically by either N-acetylcysteine (NAC) or the G6PD agonist AG-1.