Frontiers | The role of Aha1 in cancer and neurodegeneration
Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, United States The 90 kDa Heat shock protein (Hsp90) is a family of ubiquitously expressed molecular chaperones responsible for the stabilization and maturation of > 400 client proteins. Hsp90 exhibits dramatic conformational changes to accomplish this, which are regulated by partner proteins termed co-chaperones. One of these co-chaperones is called the activator or Hsp90 ATPase activity homolog 1 (Aha1) and is the most
