Frontiers | Reproductive hormones and sex chromosomes drive sex differences in the sleep–wake cycle
1 Department of Integrative Biology and Physiology, College of Life Sciences, University of California, Los Angel es, Los Angeles, CA, United States 2 Department of Neurobiology, Morehouse School of Medicine, Atlanta, GA, United States There are well-documented gender differences in the risk and severity of sleep disorders and associated comorbidities. While fundamental sex differences in sleep regulatory mechanisms may contribute to gender disparities, biological responses to sleep loss and stress may