Exploring the depth and breadth of the genomics toolbox during the COVID-19 pandemic: insights from Aotearoa New Zealand – BMC Medicine

Background Genomic technologies have become routine in the surveillance and monitoring of the coronavirus disease 2019 (COVID-19) pandemic, as evidenced by the millions of SARS-CoV-2 sequences uploaded to international databases. Yet the ways in which these technologies have been applied to manage the pandemic are varied. Main text Aotearoa New Zealand was one of a small number of countries to…

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Source: BioMed Central

Categories: Infectious Disease, Latest Headlines

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Impact of type 2 diabetes on life expectancy and role of kidney disease among inpatients with heart failure in Switzerland: an ambispective cohort study – Cardiovascular Diabetology

Background Type 2 diabetes (T2D) is expected to worsen the prognosis of inpatients with heart failure (HF) but the evidence from observational studies is inconsistent.…

BMC July 18, 2023

Metagenomic assessment of gut microbial communities and risk of severe COVID-19 – Genome Medicine

Background The gut microbiome is a critical modulator of host immunity and is linked to the immune response to respiratory viral infections. However, few studies…

BMC July 18, 2023

Management of penile post-circumcision ischemia by pentoxifylline infusion and hyperbaric oxygen therapy – BMC Urology

Background Post-circumcision penile ischemia is a devastating complication. We will present our experience in managing children with various forms of penile ischemia. Materials and methods…

BMC July 18, 2023

Protein length distribution is remarkably uniform across the tree of life – Genome Biology

Background In every living species, the function of a protein depends on its organization of structural domains, and the length of a protein is a…

BMC July 18, 2023

The emerging role of MicroRNA-182 in tumorigenesis; a promising therapeutic target – Cancer Cell International

A wide range of studies have indicated that microRNAs (miRNAs), a type of small single-stranded regulatory RNAs, are dysregulated in a different variety of human…

BMC July 18, 2023

Post-progression treatment in cancer randomized trials: a cross-sectional study of trials leading to FDA approval and published trials between 2018 and 2020 – BMC Cancer

Background Suboptimal treatment upon progression may affect overall survival (OS) results in oncology randomized controlled trials (RCTs). We aim to assess the proportion of trials…

Vinay Prasad July 18, 2023

Effective communications strategies to increase the impact of environmental health research – Environmental Health

Background Per- and polyfluoroalkyl substances (PFAS) are the subject of a growing body of research with the potential to positively impact public and ecological health.…

Medical Xpress July 18, 2023

A curated benchmark of enhancer-gene interactions for evaluating enhancer-target gene prediction methods – Genome Biology

Background Many genome-wide collections of candidate cis-regulatory elements (cCREs) have been defined using genomic and epigenomic data, but it remains a major challenge to connect…

conciergedoc July 18, 2023

Neighborhood socioeconomic deprivation, healthcare access, and 30-day mortality and readmission after sepsis or critical illness: findings from a nationwide study – Critical Care

Background To determine if neighborhood socioeconomic deprivation independently predicts 30-day mortality and readmission for patients with sepsis or critical illness after adjusting for individual poverty,…

ATS BSHSR July 18, 2023

Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for autism genes – Clinical Epigenetics

Background With the growing availability of cannabis and the popularization of additional routes of cannabis use beyond smoking, including edibles, the prevalence of cannabis use…

BMC July 17, 2023

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