Editors’ Selections from Relevant Scientific Publications
Physical activity delays PDAC development (by Pita-Grisanti et al via Cancer Research)A new study investigated the impact of physical activity on inflammation and the development of obesity-associated pancreatic ductal adenocarcinoma (PDAC). Using a genetically engineered mouse model with pancreatic-specific inducible KrasG12D expression, Pita-Grisanti and colleagues found that physical activity reduced weight gain, suppressed systemic inflammation, delayed tumor progression, and decreased proinflammatory signals in adipose tissue, particularly when diet-induced obesity was concurrent with KrasG12D expression. However, neither physical activity alone nor in combination with diet-induced weight loss or chemotherapy prevented tumor growth in orthotopic mouse models, regardless of obesity status. Additionally, the researchers observed decreased levels of proinflammatory cytokines and growth factors in 12 overweight or obese adults who participated in a 10-week voluntary running program. O
