Deletion of AMP-activated protein kinase impairs metastasis and is rescued by ROS scavenging or ectopic CD36 expression
Ramakrishnan et al. deleted AMPK in a spontaneous breast cancer metastasis mouse model and metastatic cell lines and showed that it is required for breast cancer metastasis. AMPK is required to mitigate ROS levels by generating NADPH, and thus, antioxidants could restore metastasis in AMPK-deficient cells.