COVID drug Paxlovid was hailed as a game-changer. What happened?
Insufficient investment and fears about rebound and side effects are driving down use of a lifesaving antiviral.
Related Articles
What have we learned about TP53-mutated acute myeloid leukemia?
Blood Cancer Journal – What have we learned about TP53-mutated acute myeloid leukemia?
Spatial transcriptomic clocks reveal cell proximity effects in brain ageing
Nature – A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects…
TIGIT and PD-L1 co-blockade promotes clonal expansion of multipotent, non-exhausted antitumor T cells by facilitating co-stimulation
Nature Cancer – Mellman and colleagues present a multiomic single-cell analysis of the effects of combined anti-TIGIT and anti-PD-1 blockade on T cell populations trafficking…
Giant study finds untrustworthy trials pollute gold-standard medical reviews
Nature – Two-year collaboration aims to create tools to help counter the tide of flawed research.
Abatacept for myositis
Nature Reviews Rheumatology – In a phase III clinical trial of abatacept for idiopathic inflammatory myopathy, the primary endpoint was not met but the results…
European expert recommendations for managing systemic sclerosis and its complications
Nature Reviews Rheumatology – The updated 2023 EULAR recommendations for treatment of systemic sclerosis bring notable changes to recommendations for skin, peripheral vascular disease, interstitial…
Multiple insular-prefrontal pathways underlie perception to execution during response inhibition in humans
Nature Communications – Osada et al. used MRI and brain stimulation to outline the macroscopic cerebral circuits for response inhibition: visual cortex→dorsal anterior insula→inferior…
Canonical androgen response element motifs are tumor suppressive regulatory elements in the prostate
Nature Communications – Androgen response elements (AREs) regulation produce opposite effects in normal and cancer prostate cells. Here, authors engineer a modifier of ARE-containing chromatin…
PDAC: advances in tumour microenvironment, microbiome and AI
Nature Reviews Gastroenterology & Hepatology – Pancreatic cancer remains one of the most challenging malignancies, with a very poor prognosis. Current research is focused on…
PDAC: advances in tumour microenvironment, microbiome and AI
Nature Reviews Gastroenterology & Hepatology – Pancreatic cancer remains one of the most challenging malignancies, with a very poor prognosis. Current research is focused on…