Central Body Fat Distribution and Kidney Function after… : Clinical Journal of the American Society of Nephrology
distribution measures are associated with long-term kidney function after donor nephrectomy. We hypothesized that higher BMI, waist circumference (WC), and waist-to-height ratio (WHtR) were associated with lower kidney function long term after donation. Methods The study population consisted of living kidney donors. BMI, WC, and WHtR were measured during donor screening. The outcome postdonation kidney function was assessed using measured GFR (mGFR) (mGFR, 125I-iothalamate infusion) at 3 months (n=1042), 5 years (n=556), and 10 years (n=210) of follow-up. Primary multivariable linear regression analyses were performed with BMI and WC and secondary analyses with WHtR. Linear mixed models were performed to investigate change in postdonation eGFR. Results The donor age was 52±11 years, and 48% were male. The mean BMI was 26.1±3.6 kg/m2, and WC was 91±11 cm. Higher predonation BMI was associated with lower mGFR throughout follow-up: −1.35 (95% confidence interval [CI], −1.95 to −0.80), −1.