CDK1-PP2A-B55 interplay ensures cell cycle oscillation via Apc1-loop300
Chia et al. reveal PP2A-B55’s crucial role in APC/C phospho-regulation, showing that its mitotic activation leads to APC/C inactivation by blocking Cdc20’s binding via Apc1-loop300 dephosphorylation. This discovery emphasizes the CDK-PP2A axis’s pivotal role in controlling cell cycle oscillation through APC/C regulation.