CD5-positive high-grade B-cell lymphoma with MYC, BCL2, and BCL6 rearrangements
A 48-year-old man with an unknown medical history presented with fatigue and weakness. His complete blood count revealed a white blood cell count of 221 × 10⁹/L, hemoglobin 8.8 g/dL, and platelet count 110 × 10⁹/L. Peripheral blood smears showed numerous large malignant cells with blastoid features and prominent nucleoli (panel A; Wright-Giemsa stain, 100× lens objective). Flow cytometry of peripheral blood specimen identified 77% abnormal B cells with the following immunophenotype: CD3 − /CD5 + /CD10 −
