An armed anti-immunoglobulin light chain nanobody protects mice against influenza A and B infections
A nanobody-based composite recruits polyclonal immunoglobulins, attracts immune effectors, and kills influenza virus–infected cells.
A nanobody-based composite recruits polyclonal immunoglobulins, attracts immune effectors, and kills influenza virus–infected cells.
Human IgG3 with its unique long hinge is a potent activator of intracellular antiviral immunity mediated by TRIM21 and complement.
Targeting PD-1+ cells promotes immune tolerance via peripheral clonal deletion of antigen-specific T cells.
A subset of CD8 T cells with a terminally exhausted epigenetic profile expressed IFN-γ, granzymes, and perforin in bone marrow.
Targeting of GALT by anti-α4β7 therapy is associated with therapeutic responses in ulcerative colitis.
A subset of CD8 T cells with a terminally exhausted epigenetic profile expressed IFN-γ, granzymes, and perforin in bone marrow.
Allogeneic CAR-DNTs with minimal genetic modification show potent anti-tumor activity without off-tumor toxicities.
Spatially resolved profiling of the melanoma microenvironment reveals correlates of response to immune checkpoint inhibitors.
Targeting of GALT by anti-α4β7 therapy is associated with therapeutic responses in ulcerative colitis.
The transcriptional regulator Trim33 controls Flt3L-driven dendritic cell differentiation.
Division of labor among resident tissue macrophages is vital for proper tissue function during homeostasis.