Intranasal or intramuscular immunization of ChAd-SARS-CoV-2, a chimpanzee adenoviral vaccine encoding stabilized spike protein, prevents SARS-CoV-2 lung infection and pneumonia in mice. In particular, intranasally delivered ChAd-SARS-CoV-2 uniquely prevents both upper and lower respiratory tract infections, potentially protecting against SARS-CoV-2 infection and transmission.
Using the reconstituted presynaptic terminal local vesicle transport as a paradigm, Qiu and Wu et al. demonstrate that short-distance and directional vesicle transport can be achieved…
The flexible scaffold-based cheminformatics approach (FSCA) unlocks the potential of drug design to create polypharmacological drugs that open up treatment possibilities for complex brain disorders.
A 3D model of an intact Carnegie stage 8 human embryo is constructed from spatial transcriptomics profiling of serial transverse sections.
IGSF8, aberrantly expressed on malignant cells, functions as an innate immune checkpoint that inhibits cytotoxicity of natural killer cells. A monoclonal antibody targeting IGSF8 alone,…
The molecular mechanisms regulating stem cell niche formation are poorly understood. Here, an epitranscriptomic program relying on Mettl3 is uncovered that is distinctly important for…
Naturally inspired protein engineering produces synpoptosis circuits that programmably control user-selectable death programs in target mammalian cells.
(Cell 186, 147–161.e1–15; January 5, 2023)
Zong et al. identified the tumor-derived L-lactate as a natural suppressor of p53 and screened out AARS1 as an intracellular L-lactate sensor and lactyl-transferase that mediates…
The microbial bile acid 3-succinylated cholic acid is biosynthesized by BAS-suc, an enzyme annotated as β-lactamase in Bacteroides uniformis, and it alleviates MASH progression by…
Brown fat contributes to systemic glucose homeostasis by providing BCAA-nitrogen-derived metabolites, including glutathione, to the liver, a function that is distinct from the well-known role…
