Major Finding: Cancer cells transfer mitophagy-resistant mitochondria to tumor-infiltrating lymphocytes (TIL) that impair antitumor activity. Concept: Deubiquitinase USP30 protects cancer cell-derived mitochondria from ROS-induced mitophagy in TILs.Impact: Inhibiting mitochondrial transfer may improve responses to immune checkpoint inhibitors in certain cancers.
Zhang et al. investigate immune cell dynamics in TNBC patients treated with paclitaxel, nab-paclitaxel, and combinations with atezolizumab. They identify distinct underlying cellular mechanisms, revealing that…
Although gallbladder and bile duct cancers are different diseases, they’re often discussed together. They each have a connection to bile, a fluid that helps with…
Get the inside scoop from Drs Lou, Patel, and Beg on the top takeaways to come out of the 2025 Gastrointestinal Cancers Symposium.
Patients with EGFR-mutated non-small cell lung cancer treated with osimertinib experienced more cancer therapy-related cardiac events than those treated with other EGFR tyrosine kinase inhibitors.“Despite…
Over the past two decades, Paul Nghiem, MD, PhD, and the Nghiem Lab have championed innovations in MCC treatment, delivering new treatment options, setting ever-higher…
Panelists discuss how emerging therapies like CC-486, venetoclax, and menin inhibitors are reshaping treatment strategies for relapsed and refractory acute myeloid leukemia while debating the…
A phase 1 study of a personalized cancer vaccine demonstrated antitumor immunity in all treated patients with resected renal cell carcinoma.
Explore the latest findings from a real-world data analysis on the effectiveness of immunotherapy in treating metastatic biliary tract cancer (mBTC) with spe…
One of the most frequent questions asked by patients with monoclonal gammopathies is “Doctor, how long has this problem been there?” To this question, answ
