-
Mashup Score: 22
Major Finding: HLA-DR+ CD74+ neutrophils activate antitumor T cells and enhance the efficacy of immunotherapy. Concept: A single-cell neutrophil atlas reveals an antigen-presenting population with clinical significance. Impact: This study proposes a therapeutic strategy to harness the antitumor function of neutrophils.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
-
Mashup Score: 18Tumor Cell Copy Number Alterations Exhibit Tissue Specificity - 2 month(s) ago
Major Finding: Intrinsic tissue specificity underlies patterns of copy number alterations observed in cancer. Approach: A forward genetic screen was used to assess the impact of different aneuploidy events on cellular fitness. Impact: Pro-tumorigenic mechanisms are associated with tumor-specific chromosome-scale copy number alterations.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
-
Mashup Score: 10Distinct DNA Replication Machinery Preserves Centromere Integrity - 2 month(s) ago
Major Finding: Unique DNA replication mechanisms at centromeres help prevent genomic instability and aneuploidy. Concept: Translesion synthesis enables tolerance of centromeric DNA damage to prevent centromere breakage. Impact: Drugs that exploit centromere fragility have therapeutic potential in precancerous lesions or tumors.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
-
Mashup Score: 7Telomerase Can Convert DNA Double-Strand Breaks into Telomeres - 2 month(s) ago
Major Finding: Human telomerase can add telomeric DNA to double-strand breaks, leading to neotelomere formation. Concept: ATR signaling represses telomerase and subsequent neotelomere formation at resected double-strand breaks. Impact: These results suggest that tumor cells could use this process to mitigate genomic instability.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
-
Mashup Score: 19SMARCAL1 Favors Tumor Immune Evasion Through Dual Mechanisms - 2 month(s) ago
Major Finding: SMARCAL1 drives tumor immune escape by suppressing innate immune signaling and inducing PD-L1 expression. Concept: SMARCAL1 represses activation of the cGAS-STING pathway and cooperates with JUN to enhance PD-L1 expression. Impact: These results suggest that SMARCAL1 could be a promising cancer immunotherapy target.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
-
Mashup Score: 12
Major Finding: 7-Dehydrocholesterol (7-DHC) accumulation prevents phospholipid autoxidation and suppresses ferroptosis. Concept: Pharmacologic inhibition of 7-DHC biosynthesis promotes ferroptosis and inhibits tumor growth. Impact: These results suggest that pharmacologic manipulation of 7-DHC levels can be an effective antitumor strategy.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet-
#ResearchWatch: 7-Dehydrocholesterol Suppresses Ferroptosis & Phospholipid Peroxidation, a summary of the papers by Porto Freitas, @HamedAlborzy, @AncelyF, @AngeliFriedmann et al. and Li, Ran, Duan, Jin, Wang et al. https://t.co/YcxFgcMe4K @RVZ_Wuerzburg @Uni_WUE @university_tj https://t.co/UUcbetbdkk
-
-
Mashup Score: 8Relative Scarcity of Disseminated Tumor Cells Enables Immune Evasion - 3 month(s) ago
Major Finding: The relative scarcity of disseminated tumor cells enables their evasion of antitumor immunity. Concept: Increased T-cell effector:target ratios promote tumor cell clearance in an MHC-independent manner. Impact: Therapies that increase tumor-specific T-cell abundance may eliminate DTCs and prevent recurrence.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
-
Mashup Score: 19Validate User - 3 month(s) ago
We are sorry, but we are experiencing unusual traffic at this time. Please help us confirm that you are not a robot and we will take you to your
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
-
Mashup Score: 7IL17-Mediated Gut Dysbiosis Promotes the Growth of Distant Tumors | Cancer Discovery News | American Association for Cancer Research - 3 month(s) ago
Major Finding: Disruption of IL17 signaling induces intestinal microbial dysbiosis that promotes remote tumor growth. Concept: Microbial dysbiosis-induced Th17 and B cells synthesize and distribute IL17 to distant tumors. Impact: These results show that inhibition of IL17-IL17RA signaling could abrogate systemic antitumor effects. DOI: https://doi.org/10.1158/2159-8290.CD-RW2024-009 You do not currently have access to this content. Don’ t already have an account? Register You could not be signed in.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
-
Mashup Score: 8Stromal Density Regulates Stemness and Cancer Risk in Mammary Tissue | Cancer Discovery News | American Association for Cancer Research - 3 month(s) ago
Major Finding: Stromal stiffness increases the abundance of mammary epithelial progenitors and raises cancer risk. Concept: Progesterone-induced RANK signaling and integrin mechanosensing drive basal progenitor expansion. Impact: Targeting RANK may prevent tumor development or progression in patients with dense breast tissue. DOI: https://doi.org/10.1158/2159-8290.CD-RW2024-008 You do not currently have access to this content. Don’ t already have an account? Register You could not be signed in. Please
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
#ResearchWatch: Antigen-Presenting Neutrophils Enhance T-Cell–Mediated Tumor Immunity, summarizing the work of Yingcheng Wu, Jiaqiang Ma, Xupeng Yang, Fang Nan, Tiancheng Zhang, Li Yang, Jia Fan, Xiaoming Zhang, Qiang Gao et al. https://t.co/kT1aZATLId @FudanUni https://t.co/3II3t7mC9X