A white-knuckle ride of open COVID drug discovery
In early 2020, a spontaneous global collaboration came together to design a new, urgent antiviral treatment. There are lessons in what happened next.
Related Articles
Cryogenic III-V and Nb electronics integrated on silicon for large-scale quantum computing platforms
Nature Communications – The power consumption of control/readout electronics remains a limiting factor for large-scale quantum computers. Here, the authors demonstrate III–V semiconductor and…
Ultrathin polymer membrane for improved hole extraction and ion blocking in perovskite solar cells
Nature Communications – The operational lifetimes of n-i-p perovskite solar cells have been limited by the layer-to layer ion diffusion in the perovskite/hole-transport layer heterojunction.…
Aspartate signalling drives lung metastasis via alternative translation
Nature – Aspartate in the tumour environment activates the N-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis.
2024 FDA approvals
Nature Reviews Drug Discovery – The FDA approved 50 new therapeutics in 2024, with green lights for a novel schizophrenia drug, a first NASH medicine…
Zoonotic transmission of novel Influenza A variant viruses detected in Brazil during 2020 to 2023
Nature Communications – Human infections with swine-origin influenza A viruses occur sporadically. Here, the authors describe the genomic and epidemiological characteristics of eight cases detected…
IL-22 protects against stress-induced anxiety
Nature Reviews Immunology – Stress-induced gut leakage and immune activation lead to the release of IL-22, which acts directly on septal neurons in the brain…
cfDNA screening for fetal aneuploidy facilitates maternal cancer detection
Nature Reviews Clinical Oncology – cfDNA screening for fetal aneuploidy facilitates maternal cancer detection
Cancer immune evasion, immunoediting and intratumour heterogeneity
Nature Reviews Immunology – Here the authors describe the different ways that cancer cells evade the immune system and how these mechanisms impact immunoediting and…
Targeting common disease pathomechanisms to treat amyotrophic lateral sclerosis
Nature Reviews Neurology – This Review explores several key dysregulated pathways in ALS (RNA processing, proteostasis, metabolism and inflammation) as well as evolving efforts to…
The spleen in ischaemic heart disease
Nature Reviews Cardiology – In this Review, Heusch and Kleinbongard describe the deleterious and protective roles of the spleen in the inflammatory processes of atherosclerosis,…
