Shen et al. show that the activity of a ubiquitous enzyme, CK1α, is autoinhibited upon the stimulation of Wnt signaling. The underlying mechanism involves the rearrangement of a multiprotein complex consisting of CK1α, PP2A, and AXIN. The authors further illustrate the importance of CK1α autoinhibition in colorectal cancer growth.
A new Canadian study shows a tripling of schizophrenia cases linked to cannabis use disorder since the country legalized it.
Currently available therapies for Hunter syndrome don’t cross the blood-brain barrier to address cognitive symptoms of the inherited enzyme deficiency. Denali Therapeutics’ technology gets its…
The stop-work order on U.S.A.I.D.-funded research has left thousands of people with experimental drugs and devices in their bodies, with no access to monitoring or…
The vaccine generated robust immune response in nine patients with advanced disease
Scripps Research scientists discovered that some sections of the hormone-carrying molecule transthyretin (left) are in constant motion (right), which may explain why the protein can…
A recent Mayo Clinic study highlights how a new debriefing tool is helping to improve the mental well-being of nurses.
This cohort study evaluates changes in characteristics of young aduts who carried handguns from 2019 to 2021.
Cristina Brennan can hear the clock ticking. At the end of the year, her 12-year-old son Tristan will no longer have free access to a…
U.S. District Judge George O’Toole announced at a brief hearing on Thursday that he would block the Trump administration from taking steps to implement the…
The drug, Journavx, from Vertex Pharmaceuticals, reduced pain after surgery in clinical trials. Experts hope it can lead to fewer opioid prescriptions.
