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Mashup Score: 1RFA-RM-22-019: NIH Directors New Innovator Award Program (DP2 Clinical Trial Optional) - 2 year(s) ago
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: NIH Directors New Innovator Award Program (DP2 Clinical Trial Optional) RFA-RM-22-019. RMOD
Source: grants.nih.govCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 5GitHub - mainciburu/WAT3R: Workflow for the Association of T-cell receptors from 3' single-cell RNA-seq (WAT3R) - 2 year(s) ago
Workflow for the Association of T-cell receptors from 3′ single-cell RNA-seq (WAT3R) – GitHub – mainciburu/WAT3R: Workflow for the Association of T-cell receptors from 3′ single-cell RNA-se…
Source: GitHubCategories: Hem/Oncs, Latest HeadlinesTweet-
Excellent work @MarinaAinciburu Duncan Morgan @EAKDePasquale Chris Love & @FelipeProsper! Stay tuned for an update on single-cell TCR sequencing https://t.co/80urJsEAxk 👩‍💻 #ScienceTwitter https://t.co/J156HqFAfx
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Mashup Score: 36Enhanced recovery of single-cell RNA-sequencing reads for missing gene expression data - 2 year(s) ago
Droplet-based 3’ single-cell RNA-sequencing (scRNA-seq) methods have proved transformational in characterizing cellular diversity and generating valuable hypotheses throughout biology[1][1],[2][2]. Here we outline a common problem with 3’ scRNA-seq datasets where genes that have been documented to be expressed with other methods, are either completely missing or are dramatically under-represented…
Source: bioRxivCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @Allan_HPool: First Pool Lab pre-print: https://t.co/e3vDzRXPrr. We resolve a major pain with 3’ single-cell RNA-sequencing (10x Genomic…
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Mashup Score: 2Single-Cell Multiomics Reveals Clonal T-Cell Expansions and Exhaustion in Blastic Plasmacytoid Dendritic Cell Neoplasm - 2 year(s) ago
The immune system represents a major barrier to cancer progression, driving the evolution of immunoregulatory interactions between malignant cells and T-cells in the tumor environment. Blastic plasmacytoid dendritic cell neoplasm (BPDCN), a rare acute leukemia with plasmacytoid dendritic cell (pDC) differentiation, provides a unique opportunity to study these interactions. pDCs are key producers…
Source: FrontiersCategories: Hem/Oncs, Latest HeadlinesTweet-
For human bone marrow mononuclear cells 🦴 10x 3’ v3/v3.1 data, @EricaDepoBMI did a fantastic job on this reference comprising five healthy donors https://t.co/x4kVr0zX38 1/7 https://t.co/9IWu7Xs10w
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Mashup Score: 1Quantitative and molecular differences distinguish adult human medullary and extramedullary haematopoietic stem and progenitor cell landscapes - 2 year(s) ago
In adults, the bone marrow (BM) is the main site of haematopoietic stem and progenitor cells (HSPCs) maintenance and differentiation. It is known that other anatomical sites can contribute significantly to blood production under stress conditions. However limited tissue availability restricts our knowledge on the cellular, molecular and functional composition of extramedullary HSPC pools in…
Source: bioRxivCategories: Hem/Oncs, Latest HeadlinesTweet-
For more progenitor cell granularity, check out this work. Anything coming from the Laurenti lab you can be sure is accurate https://t.co/eiyXLLiYqn 2/7
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Mashup Score: 1T cells in BPDCN – Van Galen Lab - 2 year(s) ago
Download Processed Data These files contain gene expression and cell annotations, not TCR sequencing data (which is on GEO). The data were generated using 10x 3′ v3.0 and v3.1 protocols. The healthy control object contains 25,726 high-quality cells from five donors.
Source: vangalenlab.bwh.harvard.eduCategories: Hem/Oncs, Latest HeadlinesTweet-
For accessibility, I saved Seurat objects for #1 here https://t.co/ZDTwqVlNTC and #3 here https://t.co/fip5RL704j @satijjalab 4/7
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Mashup Score: 1JCI Insight - Human bone marrow assessment by single-cell RNA sequencing, mass cytometry, and flow cytometry - 2 year(s) ago
Research ArticleHematologyImmunology Free access | 10.1172/jci.insight.124928 Katherine E. Lindblad,1 Meghali Goswami,1 Gege Gui,1 Pradeep K. Dagur,2 Catherine Lai,1 Laura W. Dillon,1 J. Philip McCoy,2 and Christopher S. Hourigan1 1Laboratory of Myeloid Malignancies, National Heart Lung and Blood Institute,…
Source: insight.jci.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
While I haven’t used these myself, here are two more resources: https://t.co/1ixszRHY7y @DrChrisHourigan https://t.co/lYK06kala0 @shtriana @DominikVonficht @JoppSaile @larsplus @haas_lab 5/7 https://t.co/hJ6knxbdLU
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Mashup Score: 1GitHub - mainciburu/WAT3R: Workflow for the Association of T-cell receptors from 3' single-cell RNA-seq (WAT3R) - 2 year(s) ago
Workflow for the Association of T-cell receptors from 3′ single-cell RNA-seq (WAT3R) – GitHub – mainciburu/WAT3R: Workflow for the Association of T-cell receptors from 3′ single-cell RNA-se…
Source: GitHubCategories: Hem/Oncs, Latest HeadlinesTweet-
I look forward to trying scRepertoire in our upcoming projects, thanks for including WAT3R! 🦠🔧🟣 @MarinaAinciburu @EricaDepoBMI @FelipeProsper https://t.co/80urJsmrjc https://t.co/FkCvWSTPsU https://t.co/Pid5FEVsgz
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Mashup Score: 0speedup a few R steps with data.table package by scfurl · Pull Request #7 · mainciburu/WAT3R - 2 year(s) ago
Hi @petervangalen – here are a few changes that should speed up a few of the R steps – please note I didn’t check these in a full Docker container, just locally and all seemed to work fine. Hope i…
Source: GitHubCategories: Hem/Oncs, Latest HeadlinesTweet-
Can this mode of science be extended to other areas? A helpful developer (unknown to me) pushed an improvement to our @github software *while* we are working on the paper revisions 💻🤝 https://t.co/yELzLnYz7R
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Mashup Score: 5Cancer stem cells: The adventurous journey from hematopoietic to leukemic stem cells - 2 year(s) ago
This year’s Gairdner Foundation Award for Biomedical Research is awarded to John Dick for the discovery of leukemic stem cells and the hierarchical organization of acute myeloid leukemias. His work laid the foundation for the cancer stem cell model with numerous clinical implications for hematopoietic malignancies and solid tumors.
Source: CellCategories: Hem/Oncs, Latest HeadlinesTweet-
Nice overview of the origin of the cancer stem cell model built on the legacy of John Dick by @haas_lab and Andreas Trumpp 📄 “The adventurous journey from hematopoietic to leukemic stem cells” https://t.co/1fYtmTXJj7
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* details are important but I think we can learn from this grant mechanism https://t.co/MGpsebn4SE @NIH