• Mashup Score: 1
    A Vaccine for Pancreatic Cancer Treatment? - 12 month(s) ago

    I have to say, this new paper is good news on the oncology front. It’s from researchers at Sloan-Kettering and BioNTech (among others) and presents the results of a small trial treating patients with pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC). This is another crack at the “personalized cancer therapy” idea and simultaneously at the “cancer vaccine” idea, and it’s fair…

    Source: www.science.org
    Categories: Hem/Oncs, Latest Headlines
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      TheVinodLab

      Nice summary of "effect size" in #mRNAvaccines for #PancreaticCancer in @ScienceMagazine 👇🏽 https://t.co/8y74mxRNEQ But: 50% no response = ❓as non-responders enriched (not ss) in pts with no spleen. Spleen ⬆️ IV #mRNAvaccine response (👉🏽🧵 https://t.co/8ndGZADgDH )

  • Mashup Score: 0
    Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer - Nature - 12 month(s) ago

    A phase I clinical trial of an adjuvant personalized mRNA neoantigen vaccine, autogene cevumeran, in patients with pancreatic ductal carcinoma demonstrates that the vaccine can induce T cell activity that may correlate with delayed recurrence of disease.

    Source: Nature
    Categories: Hem/Oncs, Latest Headlines
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      TheVinodLab

      ICYMI - our thread on #mRNAvaccines for #PancreaticCancer in @Nature https://t.co/d1SgGgdVHq 👇🏽 https://t.co/8ndGZADgDH + interesting take below 👇🏽 https://t.co/HMomidxcZd

  • Mashup Score: 2
    An mRNA vaccine that programs the body to fight pancreatic cancer shows early promise | CNN - 12 month(s) ago

    Of the 16 patients who were able to complete all phases of the study, eight responded to the vaccine, which taught their immune systems how to recognize and fight off the cancer cells. None of those eight has seen their cancer return.

    Source: CNN
    Categories: Hem/Oncs, Latest Headlines
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      TheVinodLab

      ICYMI 👇🏽 Nice description of our work on #mRNAvaccines for #PancreaticCancer from @CNN Delves a little into why 50% non-response to vaccines (is it the spleen?) https://t.co/YoEPM5wnA8 Our tweetorial on the research 👇🏽 https://t.co/8ndGZADgDH @drsanjaygupta

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