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Mashup Score: 128The persistence of SARS-CoV-2 in tissues and its association with long COVID symptoms: a cross-sectional cohort study in China - 18 day(s) ago
Our findings suggest that residual SARS-CoV-2 can persist in patients who have recovered from mild COVID-19 and that there is a significant association between viral persistence and long COVID symptoms. Further research is needed to verify a mechanistic link and identify potential targets to improve long COVID symptoms.
Source: www.thelancet.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 108Social histories of public health misinformation and infodemics: case studies of four pandemics - 18 day(s) ago
Recognition of misinformation as a public health threat and interest in infodemics, defined as an inundation of information accompanying an epidemic or acute health event, have increased worldwide. However, scientists have no consensus on how to best define and identify misinformation and other essential characteristics of infodemics. We conducted a narrative review of secondary historical sources to examine previous infodemics in relation to four infectious diseases associated with pandemics (ie, smallpox, cholera, 1918 influenza, and HIV) and challenge the assumption that misinformation is a new phenomenon associated with increased use of social media or with the COVID-19 pandemic.
Source: www.thelancet.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 19
In their study in The Lancet Infectious Diseases, Wenting Zuo and colleagues collected tissue samples from 225 patients who had recovered from mild COVID-19 and found that SARS-CoV-2 viral RNA was distributed across ten distinct solid tissues, plasma, and blood cells up to 4 months after infection. Importantly, detection of viral RNA, and higher virus copy numbers, were significantly associated with post-COVID-19 condition (also known as long COVID; odds ratio for association of persistent viral RNA with long COVID symptoms=5·17, 95% CI 2·64–10·13, p<0·0001).
Source: www.thelancet.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 128The persistence of SARS-CoV-2 in tissues and its association with long COVID symptoms: a cross-sectional cohort study in China - 18 day(s) ago
Our findings suggest that residual SARS-CoV-2 can persist in patients who have recovered from mild COVID-19 and that there is a significant association between viral persistence and long COVID symptoms. Further research is needed to verify a mechanistic link and identify potential targets to improve long COVID symptoms.
Source: www.thelancet.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 103Social histories of public health misinformation and infodemics: case studies of four pandemics - 19 day(s) ago
Recognition of misinformation as a public health threat and interest in infodemics, defined as an inundation of information accompanying an epidemic or acute health event, have increased worldwide. However, scientists have no consensus on how to best define and identify misinformation and other essential characteristics of infodemics. We conducted a narrative review of secondary historical sources to examine previous infodemics in relation to four infectious diseases associated with pandemics (ie, smallpox, cholera, 1918 influenza, and HIV) and challenge the assumption that misinformation is a new phenomenon associated with increased use of social media or with the COVID-19 pandemic.
Source: www.thelancet.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 64Global burden associated with 85 pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019 - 24 day(s) ago
Our detailed breakdown of DALYs associated with a comprehensive list of pathogens on a global, regional, and country level has revealed the magnitude of the problem and helps to indicate where research funding mismatch might exist. Given the disproportionate impact of infection on low-income and middle-income countries, an essential next step is for countries and relevant stakeholders to address these gaps by making targeted investments.
Source: www.thelancet.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 8The continuing challenge of infectious diseases - 24 day(s) ago
In 2019, 2540 million (95% uncertainty interval [UI] 2290–2810) disability-adjusted life years (DALYs) were attributed to non-communicable and communicable diseases and injuries globally.1 In The Lancet Infectious Diseases, the IHME Pathogen Core Group have now estimated a burden of 704 million (610–820) DALYs to be associated with 85 pathogens (encompassing causative agents, pathogen groups, infectious diseases, and aggregate categories),2 or more than a quarter (27·7%) of all DALYs attributable to disease and injury, in 2019.
Source: www.thelancet.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 46
Substantial progress has been made in reducing LRI mortality, but the burden remains high, especially in low-income and middle-income countries. During the COVID-19 pandemic, with its associated non-pharmaceutical interventions, global incident LRI cases and mortality attributable to influenza and RSV declined substantially. Expanding access to health-care services and vaccines, including S pneumoniae, H influenzae type B, and novel RSV vaccines, along with new low-cost interventions against S aureus, could mitigate the LRI burden and prevent transmission of LRI-causing pathogens.
Source: www.thelancet.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 17
This first-in-human aerosol BCG controlled human infection model was sufficiently well tolerated. Further work will evaluate the utility of this model in assessing vaccine efficacy and identifying potential correlates of protection.
Source: www.thelancet.comCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 0A new tool for accelerating tuberculosis vaccine development - 26 day(s) ago
Tuberculosis remains a formidable global health challenge, causing substantial morbidity and mortality due to the limited protection in the lungs provided by the current BCG vaccine.1 The urgent need for an effective tuberculosis vaccine has prompted innovative approaches to accelerate vaccine development. One such approach is the use of controlled human infection models, which offer a unique opportunity to evaluate candidate tuberculosis vaccines in a cost-effective manner.2 Although the concept is not new,3 developing such models for tuberculosis research presents unique challenges because the use of Mycobacterium tuberculosis, the causative agent of tuberculosis, as a challenge agent is not ethical.
Source: www.thelancet.comCategories: General Medicine News, Infectious DiseaseTweet
New research: The persistence of SARS-CoV-2 in tissues and its association with long COVID symptoms: a cross-sectional cohort study in China https://t.co/h0K1YqABkH