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Mashup Score: 5Predictions and productions - 5 month(s) ago
We have a lamplight problem. The only drugs in our pipelines, certainly by the time they hit phase II, are those with a positive NPV. At many companies now, ‘forecasts’ that don’t exceed $2bn will see a molecule eliminated from a portfolio review. Given the 5 to 10 years from that forecast to it being proven unreliable in real practice, we need to realise that the pile of molecules we discarded may well contain more gems than the ones we kept.
Source: ideapharma.substack.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 0Niall Ferguson: We’re All Soviets Now - 5 month(s) ago
A government with a permanent deficit and a bloated military. A bogus ideology pushed by elites. Poor health among ordinary people. Senescent leaders. Sound familiar?
Source: www.thefp.comCategories: General Medicine News, Hem/OncsTweet-
Cant agree with all, and certainly not uplifting, but a worthwhile reading. https://t.co/7fkbrrpIe4
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Mashup Score: 2Checkmate Myeloma - 5 month(s) ago
The Case for Using Best Available Therapies Early
Source: myelomafighters.substack.comCategories: General Medicine News, Hem/OncsTweet-
Delighted to have this guest post with Andrew Cowan and Mary Rose. #mmsm "Checkmate Myeloma" https://t.co/hBlL6X7lu5
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Mashup Score: 1From the VisionPro community on Reddit: Do you have money? Buy - 5 month(s) ago
Explore this post and more from the VisionPro community
Source: www.reddit.comCategories: General Medicine News, Hem/OncsTweet-
https://t.co/8qMDQ2w22r
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Mashup Score: 2Incidence or T cell lymphoma in patients diagnosed with multiple myeloma or diffuse large B-cell lymphoma - 5 month(s) ago
A Komodo Real World Evidence analysis
Source: rafaelfonseca.substack.comCategories: General Medicine News, Hem/OncsTweet-
A quick reminder that CART induced T cell NHL are very rare and it should not be assumed they are always casually linked. Of all the things patients have to consider this is at best minimal/trivial, possibly a possible distraction. https://t.co/WYNwDs3aja Nature story… https://t.co/tQZetOScoo https://t.co/EgRRi0sTDT
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Mashup Score: 1Why Javier Milei Won the Presidency in Argentina - 6 month(s) ago
Summary: Once one of the world’s wealthiest nations, Argentina has suffered economic decline since the early 20th century. Argentina’s inflation and economic stagnation have led to higher time prices for basic commodities. The election of President Milei brings hope for economic revival by encouraging entrepreneurship and reducing state control, potentially restoring Argentina’s former economic power. It’s hard to find a country that is worse off today than it was in 1980. But Argentina makes the list.
Source: humanprogress.orgCategories: General Medicine News, Hem/OncsTweet-
https://t.co/jCvGXFyAte
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Mashup Score: 9Bone Disease in Myeloma: The Claws of CRAB - PubMed - 6 month(s) ago
A dynamic approach to use bisphosphonates according to biomarkers of bone metabolism is presented in the Z-MARK study by Raje and colleagues. This is a major step forward toward a rational approach to bisphosphonate usage.
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet-
@AaronGoodman33 Good general point. But as u know I’m more in the observe till true progression happens camp. Would be onboard of dynamic changes given assurance of in imminent progression. But a fracture or ARF are strong incentives. The claws of the CRAB! 🦀 https://t.co/ZjCVbAUo1y #mmsm. https://t.co/1bmPbZSvoQ
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Mashup Score: 0
Better treatments improve survival!
Source: rafaelfonseca.substack.comCategories: General Medicine News, Hem/OncsTweet-
Where does this extra survival time come if the clinical trials do not show improved overall survival? https://t.co/Mp4yqKu1Tg https://t.co/uUnqKm9fmN
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Mashup Score: 33
Read it now on PracticeUpdate.com
Source: www.practiceupdate.comCategories: General Medicine News, Hem/OncsTweet-
Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma | comment: Rafael Fonseca MD https://t.co/KQNQ6Drlhh via @practiceupdate
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Mashup Score: 6
I’ve written many columns about Venezuela, Chile, and Argentina, but only one column specifically about Mexico. Since I’m currently in Mexico City doing some meetings and research about…
Source: danieljmitchell.wordpress.comCategories: General Medicine News, Hem/OncsTweet-
Mexico's Irresponsible Populist President Proposes Election-Year Giveaway https://t.co/cKPxzRIcyX
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Thought provoking. Any asset with an NPV of less than 2B is scrapped. What was lost in the pipeline? Great write up. Uncertainty explained below: https://t.co/zKZoFyphgK @ideapharma https://t.co/qy5GWmxK6C