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Mashup Score: 1Missense Genetic Variation of ICAM1 and Incident Heart Failure - 2 year(s) ago
Immune dysregulation may play a central role in the pathogenesis of certain heart failure (HF) syndromes, but precise mechanisms remain unclear (1,2). Specifically, chronic systemic inflammation driven by comorbidities may upregulate cellular adhesion molecules (CAMs) on the surface of endothelial cells, allowing for leukocyte infiltration of various tissue beds (1). This inflammatory cascade may…
Source: Journal of Cardiac FailureCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 1
A Study of Mavacamten in Participants With HFpEF and Elevation of NT-proBNP With or Without Elevation of cTnT – Full Text View.
Source: clinicaltrials.govCategories: Cardiologists, Latest HeadlinesTweet-
@pnatarajanmd @ercgrn @IainSForrest @DoGenetics @IcahnMountSinai The EMBARK HFpEF trial is attempting to test this now (mava in pEF), by enrolling those with EF >60% and relatively preserved GLS. https://t.co/VTkJW4Bm1K Enrollment by genetic predisposition to high LVEF would be very interesting.
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Mashup Score: 3Dapagliflozin in heart failure with preserved and mildly reduced ejection fraction: rationale and design of the DELIVER trial - 3 year(s) ago
Aims Sodium–glucose co-transporter 2 (SGLT2) inhibitors, originally developed as glucose-lowering agents, have been shown to reduce heart failure hospitalizations in patients with type 2 diabetes wi…
Source: Wiley Online LibraryCategories: Cardiologists, Latest HeadlinesTweet-
@CBlumenthal2 Good question - in DELIVER, patients can be eligible with history of LVEF <40% if it were sustained during a specific procedure/event (MI, UA, CABG, AF ablation, valve surgery) as long as qualifying echo >12 weeks from event/procedure. See methods paper: https://t.co/YwkydKu8vF
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Future @IUCardsFellows fellow and current @NMCardioVasc research fellow Pedro Giro presents at #ACC23: A missense variant in ICAM1 that is common in Black individuals but rare in other race/ethnicities -> ⬆️HFpEF risk #ACC23 Sim Pub in @JCardFail: https://t.co/qvNNP2TXqe https://t.co/9Y86xLG11e