-
Mashup Score: 9Outcomes of minimal access retroperitoneal para-aortic lymphadenectomy in patients with locally advanced cervical cancer - 3 day(s) ago
To evaluate outcomes of laparoscopic retroperitoneal para-aortic lymphadenectomy for stage 1b3-3b cervical cancer.Pathology databases searched for all para-aortic lymphadenectomy cases 2005–2016. D…
Source: www.tandfonline.comCategories: General Medicine News, Oncologists2Tweet
-
Mashup Score: 29Cost-Effectiveness of Unselected Multigene Germline and Somatic Genetic Testing for Epithelial Ovarian Cancer - 21 day(s) ago
Background: Parallel panel germline and somatic genetic testing of all patients with ovarian cancer (OC) can identify more pathogenic variants (PVs) that would benefit from PARP inhibitor (PARPi) therapy, and allow for precision prevention in unaffected relatives with PVs. In this study, we estimate the cost-effectiveness and population impact of parallel panel germline and somatic BRCA testing of all patients with OC incorporating PARPi therapy in the United Kingdom and the United States compared with clinical criteria/family history (FH)–based germline BRCA testing. We also evaluate the cost-effectiveness of multigene panel germline testing alone. Methods: Microsimulation cost-effectiveness modeling using data from 2,391 (UK: n=1,483; US: n=908) unselected, population-based patients with OC was used to compare lifetime costs and effects of panel germline and somatic BRCA testing of all OC cases (with PARPi therapy) (strategy A) versus clinical criteria/FH-based germline BRCA testing
Source: jnccn.orgCategories: General Medicine News, Oncologists2Tweet
-
Mashup Score: 9Utility Scores for Risk-Reducing Mastectomy and Risk-Reducing Salpingo-Oophorectomy: Mapping to EQ-5D - 1 month(s) ago
Background: Risk-reducing mastectomy (RRM) and risk-reducing salpingo-oophorectomy (RRSO) are the most effective breast and ovarian cancer preventive interventions. EQ-5D is the recommended tool to assess the quality of life and determine health-related utility scores (HRUSs), yet there are no published EQ-5D HRUSs after these procedures. These are essential for clinicians counselling patients and for health-economic evaluations. Methods: We used aggregate data from our published systematic review and converted SF-36/SF-12 summary scores to EQ-5D HRUSs using a published mapping algorithm. Study control arm or age-matched country-specific reference values provided comparison. Random-effects meta-analysis provided adjusted disutilities and utility scores. Subgroup analyses included long-term vs. short-term follow-up. Results: Four studies (209 patients) reported RRM outcomes using SF-36, and five studies (742 patients) reported RRSO outcomes using SF-12/SF-36. RRM is associated with a lo
Source: www.mdpi.comCategories: General Medicine News, Oncologists2Tweet
-
Mashup Score: 9BRCA awareness and testing experience in the UK Jewish population: a qualitative study - 1 month(s) ago
Background 1 in 40 UK Jewish individuals carry a pathogenic variant in BRCA1/BRCA2 . Traditional testing criteria miss half of carriers, and so population genetic testing is being piloted for Jewish people in England. There has been no qualitative research into the factors influencing BRCA awareness and testing experience in this group. This study aimed to explore these and inform improvements for the implementation of population genetic testing. Methods Qualitative study of UK Jewish adults who have undergone BRCA testing. We conducted one-to-one semistructured interviews via telephone or video call using a predefined topic guide, until sufficient information power was reached. Interviews were audio-recorded, transcribed verbatim and interpreted using applied thematic analysis. Results 32 individuals were interviewed (28 carriers, 4 non-carriers). We interpreted five themes intersecting across six time points of the testing pathway: (1) individual differences regarding personal/family
Source: jmg.bmj.comCategories: General Medicine News, Oncologists2Tweet
-
Mashup Score: 9Utility Scores for Risk-Reducing Mastectomy and Risk-Reducing Salpingo-Oophorectomy: Mapping to EQ-5D - 1 month(s) ago
Background: Risk-reducing mastectomy (RRM) and risk-reducing salpingo-oophorectomy (RRSO) are the most effective breast and ovarian cancer preventive interventions. EQ-5D is the recommended tool to assess the quality of life and determine health-related utility scores (HRUSs), yet there are no published EQ-5D HRUSs after these procedures. These are essential for clinicians counselling patients and for health-economic evaluations. Methods: We used aggregate data from our published systematic review and converted SF-36/SF-12 summary scores to EQ-5D HRUSs using a published mapping algorithm. Study control arm or age-matched country-specific reference values provided comparison. Random-effects meta-analysis provided adjusted disutilities and utility scores. Subgroup analyses included long-term vs. short-term follow-up. Results: Four studies (209 patients) reported RRM outcomes using SF-36, and five studies (742 patients) reported RRSO outcomes using SF-12/SF-36. RRM is associated with a lo
Source: www.mdpi.comCategories: General Medicine News, Oncologists2Tweet
-
Mashup Score: 13Overview | Ovarian cancer: identifying and managing familial and genetic risk | Guidance | NICE - 2 month(s) ago
This guideline covers assessing the familial and genetic risk of having a pathogenic variant associated with ovarian cancer in adults
Source: www.nice.org.ukCategories: General Medicine News, Oncologists2Tweet
-
Mashup Score: 22Lynch Choices - Lynch choices - 2 month(s) ago
Lynch syndrome (‘Lynch’) is an inherited condition that increases the chance of developing certain cancers. The type of cancer depends on the genes involved. This website helps people with Lynch to make choices that are right for them. It is designed to be used with support from the genetics service, GPs, healthcare teams in the community, charities and patient groups. If you are concerned about Lynch but have not been diagnosed, please speak to your GP or genetics service. Each session below helps you
Source: canchoose.org.ukCategories: General Medicine News, Oncologists2Tweet
-
Mashup Score: 3
This economic evaluation estimates the cost-effectiveness of prevention strategies for ovarian and breast cancer among individuals with pathogenic variants in cancer susceptibility genes BRCA1, BRCA2, PALB2, RAD51C, RAD51D, and BRIP1.
Source: jamanetwork.comCategories: General Medicine News, Oncologists2Tweet
-
Mashup Score: 29Screening and prevention of ovarian cancer - 3 month(s) ago
Ovarian cancer remains the most lethal gynaecological malignancy with 314 000 cases and 207 000 deaths annually worldwide. Ovarian cancer cases and deaths are predicted to increase in Australia by…
Source: onlinelibrary.wiley.comCategories: General Medicine News, Oncologists2Tweet
-
Mashup Score: 27
This economic evaluation estimates the cost-effectiveness of prevention strategies for ovarian and breast cancer among individuals with pathogenic variants in cancer susceptibility genes BRCA1, BRCA2, PALB2, RAD51C, RAD51D, and BRIP1.
Source: jamanetwork.comCategories: General Medicine News, Oncologists2Tweet
https://t.co/9I3r0Mibu2 Paper out showing Laparoscopic retroperitoneal para-aortic lymphadenectomy is an acceptable procedure which can guide radiotherapy treatment in women with locally advanced cervical cancer. Single centre experience @BgcsFellows @wpp_wiph @ENYGO_official