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Mashup Score: 0The cell surface hyaluronidase TMEM2 plays an essential role in mouse neural crest cell development and survival - 1 year(s) ago
Author summary As a major component of the extracellular matrix, hyaluronan is particularly abundant in the extracellular matrix of embryonic tissues, where its expression is dynamically regulated during tissue morphogenetic processes. Tissue levels of hyaluronan are regulated not only by its synthesis but also by its degradation. Curiously, however, mice lacking known hyaluronidase molecules,…
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 0
Author summary Cell-free DNA (cfDNA) in various bodily fluids, for example blood plasma and urine, is of great importance for noninvasive cancer detection and noninvasive prenatal testing. Many emerging studies on the fragmentation of plasma DNA (i.e., fragmentomics) have received much recent interest. However, the fragmentomics in urinary cfDNA (ucfDNA) remained much less explored. In this…
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet-
Chen et al find that the deletion of Dnase1, but not Dnase1l3, causes dramatic alterations of ucfDNA fragmentation patterns These patterns hold potential for classifying patients with and without bladder cancer @CUHKMedicine #CancerResearch https://t.co/Nt3IOZYOw7
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Mashup Score: 0The evolutionary path of chemosensory and flagellar macromolecular machines in Campylobacterota - 1 year(s) ago
Author summary Chemosensory system is the most complicated signal transduction system in bacteria with great diversity in both composition and structural organization across species. One of its important signaling output is flagellar motility driven by a propeller, which is made of dozens of proteins and shows considerable variation and complexity surrounding the core motor structure in different…
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet-
Mo et al find that the high-torque generating flagellar motor structure of Campylobacter jejuni and Helicobacter pylori likely evolved in the last common ancestor of the Campylobacterota phylum #Genetics #Evolution https://t.co/wXvCjIO2qS
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Mashup Score: 0Dioecy and chromosomal sex determination are maintained through allopolyploid speciation in the plant genus Mercurialis - 1 year(s) ago
Author summary Polyploidization, or genome duplication, is widespread among plants, with consequences that include gene loss, genome reorganization, and large-scale changes in gene expression. These changes could also affect species with separate sexes, with implications for sex determination and the evolution of sexual dimorphism. In some plants, polyploidy may disrupt the mechanism of sex…
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet-
Toups et al show that M. canariensis arose via hybridization between the dioecious relative M. annua and an unidentified, possibly extinct, second species @mel_toups @ISTAustria @DEE_UNIL #Genetics https://t.co/soPEtObJln
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Mashup Score: 1
Author summary In plants, senescence is the final stage of development, but regeneration can help them beyond the stage. Plants regeneration is essential for propagation, and in cultivated crops to maintain excellent traits as close as possible. JA signaling can sense environmental signals and integrate various regulatory mechanisms to ensure plants regeneration occurs under optimal conditions….
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet-
Tang et al find that tomato plant repressors SlJAZ10 and SlJAZ11 mediate dark-induced leaf senescence and regeneration #Genetics https://t.co/Sen94yys7h
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Mashup Score: 0Base editing in bovine embryos reveals a species-specific role of SOX2 in regulation of pluripotency - 1 year(s) ago
Author summary The first and second cell fate decisions of a new life are important for subsequent embryonic and placental development. These events are finely controlled by a network of transcriptional factors, which are extensively characterized in mice. Species-specific roles of these proteins are emerging in mammals. Here, we develop a gene loss-of-function system by using cytosine base…
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet-
Luo et al develop a gene loss-of-function system using cytosine base editors in bovine early embryos They find that expression pattern, functional roles, and regulation of SOX2 are all different between mouse and bovine embryos #Genetics https://t.co/0vzvhOzDBx
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Mashup Score: 3Targeting early proximal-rod component substrate FlgB to FlhB for flagellar-type III secretion in Salmonella - 1 year(s) ago
Author summary Type III secretion (T3S) is the means by which proteins are secreted from the bacterial cytoplasm to build flagella for motility and injectisome structures that facilitate pathogenesis. T3S is the only secretion system known to date that undergoes a secretion-specificity switch. For the assembly of the bacterial flagellum, the T3S system initially secretes early substrates to build…
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet-
Qu et al identify important sites of interaction between an early substrate of type III secretion in #Salmonella, FlgB and a target site at the cytoplasmic base of T3S apparatus @UofUBiology #Genetics https://t.co/iPv6SPYL9o
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Mashup Score: 1PACSIN1 is indispensable for amphisome-lysosome fusion during basal autophagy and subsets of selective autophagy - 1 year(s) ago
Author summary Autophagy is an evolutionally conserved cytoplasmic degradation system in which double membrane structure called autophagosomes sequester several cytoplasmic materials and then transport to lysosomes for degradation. Previous studies mainly based on electron microscopy indicates autophagosomes either fuse with lysosomes directly or fuse with endosomes/MVB (Multi Vesicular Body),…
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet-
Oe et al identify PACSIN1 as a novel regulator of autophagy, whose function is essential for the amphisome-lysosome fusion process 🔎 https://t.co/6iRhkK6d2e #Genetics https://t.co/khTt7ZVILk
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Mashup Score: 0Two duplicated gsdf homeologs cooperatively regulate male differentiation by inhibiting cyp19a1a transcription in a hexaploid fish - 1 year(s) ago
Author summary Polyploidy generates extra chromosome sets and duplicated genes. However, how the duplicated genes co-regulate a biological process in polyploids remains largely unknown. Here, we reveal that two gsdf (gonadal somatic cell-derived factor) homeologs (gsdf-A and gsdf-B) cooperatively induce male differentiation by inhibiting cyp19a1a (cytochrome P450, family 19, subfamily A,…
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet-
Wang et al find that two gsdf homeologs cooperatively induce male differentiation by inhibiting cyp19a1a transcription in hexaploid gibel carp 🔎 https://t.co/SoKUkCa845 #Genetics https://t.co/lZtLfRbON0
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Mashup Score: 2A bistable prokaryotic differentiation system underlying development of conjugative transfer competence - 1 year(s) ago
Author summary Horizontal gene transfer processes among prokaryotes have raised wide interest, which is attested by broad public health concern of rapid spread of antibiotic resistances. However, we typically take for granted that horizontal transfer is the result of some underlying spontaneous low frequency event, but this is not necessarily the case. As we show here, mobile genetic elements…
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet-
Sulser & Vucicevic et al find that integrative and conjugative elements impose a coordinated program on the host cell in order to transfer This to an exclusive differentiated set of transfer competent cells @DMF_UNIL #Genetics https://t.co/pp2wGxPL2H
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Inubushi et al show that hyaluronidase TMEM2 plays a critical role in the development of neural crest cells and their derivatives @sbpdiscovery #Genetics https://t.co/3M3n3x9SjB