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Mashup Score: 0TRACERx - 1 year(s) ago
Cancers evolve at a dynamic pace to adapt to immune pressure, colonize new niches, and evade therapy. Tracking these changes can help us improve diagnosis, …
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 1
Plants emit species- and stress-specific airborne sounds that can be detected in acoustic chambers and greenhouses.
Source: CellCategories: Hem/Oncs, Latest HeadlinesTweet-
Nature is incredible! Stressed plants cry too. https://t.co/rEHWeWZoOL
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Mashup Score: 0
: We hypothesized that concurrent ipilimumab with chemoradiotherapy (chemoRT) followed by maintenance nivolumab would be safe for patients with unresectable stage III NSCLC. We aimed to assess the safety (phase I) and the 12-month progression-free survival (PFS) (phase II) in a multi-institution prospective trial.
Categories: Hem/Oncs, Latest HeadlinesTweet-
Yet another example that more is not better! I just can’t… :( Dose Limiting Pulmonary Toxicity in a Phase I/II Study of Radiation and Chemotherapy with Ipilimumab followed by Nivolumab for Patients with Stage III Unresectable Non-small Cell Lung Cancer https://t.co/eTGelkfplx
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Mashup Score: 0Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy - 1 year(s) ago
Li et al. uncover crosstalk between core immunogenic, metabolic, and oncogenic pathways in cancer cells during immunotherapy, which enables hyperprogressive disease (HPD) in preclinical models and correlates with immunotherapy-associated HPD in patients with cancer.
Source: Cancer CellCategories: Hem/Oncs, Latest HeadlinesTweet-
About 10% of patients experience hyper-progression after immunotherapy. This very cool paper shows that it is the beloved CD8+ T cells that drive cancer hyperprogression via IFNÎł! This alters B-catenin signaling. Great work! https://t.co/UFOdXhREVN
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Mashup Score: 0Constitutive Activation of the Tumor Suppressor p53 in Hepatocytes Paradoxically Promotes Non–Cell Autonomous Liver Carcinogenesis - 2 year(s) ago
This study reveals that activation of p53 in hepatocytes promotes liver carcinogenesis derived from HPCs, which elucidates a paradoxical aspect of a tumor suppressor p53 and novel mechanism of liver carcinogenesis.
Categories: Latest Headlines, Oncologists1Tweet-
Fascinating story how p53 *promotes* carcinogenesis in the liver. WHAT. Just when you think you know things, science surprises you. https://t.co/RBbobhSfka
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Mashup Score: 2
Mutations affecting isocitrate dehydrogenase (IDH) enzymes are prevalent in glioma, leukemia, and other cancers. Although mutant IDH inhibitors are ef…
Source: www.sciencedirect.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Beautiful translational work by a #radonc physician scientist (resident!!) whom I think did this during her Holman (🤯) time. Huge translational potential🙌 https://t.co/itdpPXBaoT
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Mashup Score: 0A p53–phosphoinositide signalosome regulates nuclear AKT activation - Nature Cell Biology - 2 year(s) ago
Chen et al. report that following genotoxic stress, a nuclear PI3K binds p53 to generate a p53–phosphoinositide signalosome that recruits AKT and its activators, resulting in nuclear AKT activation and cell survival.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
From lab next door @UWCarbone: discovery of a novel p53-PI3K-AKT nuclear (not the canonical cell membrane pathway) signalosome following genotoxic stress. Fascinating. https://t.co/aRdH8wKYD3
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Mashup Score: 3Women Who Conquer Cancer - 2 year(s) ago
Thank You for Supporting Female Oncologists! We are currently raising funds for the 2023 Women Leaders of Oncology Women Who Conquer Cancer Young Investigator Award. All additional funds will go toward our goal of raising $1.35 million for the Conquer Cancer-Women Leaders in Oncology Young Investigator Award Endowment. This will help ensure that female scientists can receive…
Source: app.mobilecause.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Women are 30% less likely than their male counterparts to receive NIH funding. Women Who Conquer Cancer @ConquerCancerFd and Women Leaders in Oncology #WLO2022 help support young female investigators. Your donation can change a woman's career! https://t.co/m8BuUb55lC
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Mashup Score: 16
Haematopoiesis has high clonal diversity up to about 65 years of age, after which diversity drops precipitously owing to positive selection acting on a handful of clones that expand exponentially throughout adulthood.
Source: NatureCategories: Latest Headlines, Oncologists1Tweet-
As we age, clonal diversity of blood cells decreases. And sorry men, but loss of the Y chromosome was frequent (females do not lose an inactive X chromosome) and this loss was positively selected for! So...X chromosomes rule, just sayin https://t.co/utTos6nqHo
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Mashup Score: 10Erin Jackson wins gold in the 500, becoming the first African American woman to win a speedskating medal. - 2 year(s) ago
Jackson, 29, was the dominant 500-meter skater in the world this year.
Source: www.nytimes.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Huge congrats to @ErinJackson480 for becoming the FIRST African American woman to win gold (or any medal) in speed skating. Amaaaazing!! https://t.co/YZiiZiuccl
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Pretty sure a world record was set yesterday: @CharlesSwanton published 7 (SEVEN) papers in Nature in 1 day. 🤯 Hot diggity damn. https://t.co/vLc4nUMAaI