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Mashup Score: 93
Brain metastases (BMs) affect an increasing number of cancer patients and are typically managed with stereotactic radiosurgery (SRS). Our institution advocates the use of Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy (PULSAR), where radiation is delivered in high-dose pulses at extended intervals allowing for treatment adaptation and easy concurrent systemic therapy integration. We explore the integration of PULSAR with central nervous system (CNS)- active drugs (CNS-aDs).
Source: www.redjournal.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 49
We read with great interest the results of the CROSSFIRE trial,1 in which patients with locally advanced pancreatic cancer were randomly assigned to receive MRI-guided stereotactic ablative body radiotherapy (SABR) or irreversible electroporation after standard FOLFIRINOX chemotherapy. The trial was stopped prematurely for futility; among the 68 patients enrolled, there was no difference in overall survival between groups (hazard ratio [HR] 1·39, 95% CI 0·84–2·30; p=0·21). We would like to discuss and highlight some of the results that should be considered when opting for SABR or irreversible electroporation for patients with locally advanced pancreatic cancer.
Source: www.thelancet.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 38Time to Slash SABR From Our Lexicon - 10 day(s) ago
In 2010, Practical Radiation Oncology (PRO) published an editorial by Loo et al, that introduced the terminology stereotactic ablative radiotherapy, for which they contrived the acronym SABR (not SAR, or SART, as one might have anticipated). Their stated premise included several opinions: a perceived difficulty in finding an appropriate nomenclature to define the emerging literature and practice of precisely targeted, high-dose, hypofractionated radiation therapy; what they believed to be lack of precision in the then operative and established terminology of stereotactic body radiation therapy (SBRT) to describe the “extreme dose intensity” (their words) being employed; that SBRT did not connote “ablative,” and; then in an ostensibly commercial turn, that the acronym SBRT was not cool (our word) enough.
Source: www.practicalradonc.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 14
External-beam radiation therapy (EBRT), and more explicitly stereotactic body radiation therapy (SBRT), is a safe and effective bridging therapy to liver transplantation for patients with hepatocellular carcinoma (HCC). However, the national prevalence and clinicopathologic parameters of patients receiving EBRT as a bridging modality in the United States are unknown. The United Network for Organ Sharing (UNOS) is a non-profit organization that manages the national liver transplant waiting list in the United States.
Source: www.redjournal.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 27Standing desks may harm your health, research finds | CNN - 11 day(s) ago
Standing desks may not improve the health risks associated with sitting at your desk all day, a new study has found.
Source: www.cnn.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 1Prospective Study of Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma on Waitlist for Liver Transplant - PubMed - 11 day(s) ago
SBRT was safe, with a significantly higher tumor control rate, reduced the risk of waitlist dropout, and should be used as an alternative to conventional bridging therapies.
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 11ClinicalTrials.gov - 11 day(s) ago
Hide glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information.
Source: clinicaltrials.govCategories: General Medicine News, Hem/OncsTweet-
Thx! Didn't know trial. Results posted: https://t.co/F2jENcy2Q5 Small trial (n=48), but #s favor SBRT > TACE for bridging: Less progression (11% v 38% at 1 yr) Less additional pre-transplant tx needed: 5% vs. 21% Better radiographic response: 95% vs. 80% 0 deaths (vs. 1) https://t.co/106oOMNom4 https://t.co/aXPyQAAbf8
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Mashup Score: 77
Liver transplantation (LT) represents the best treatment option for patients with selected hepatocellular carcinoma (HCC) but due to organ shortage most regions place limits on the size and number of tumors that qualify for this therapy. The best methods to prevent drop-out from the waiting list due to tumor progression and/or to reduce post-transplant tumor recurrence are unknown [1]. According to the American Association for the Study of Liver Diseases guidelines for the management of HCC, bridging therapies should be applied if the expected waiting time is longer than 6months [2].
Source: www.journal-of-hepatology.euCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 167NRG Oncology International Consensus Contouring Atlas on Target Volumes and Dosing Strategies for Dose-Escalated Pancreatic Cancer Radiotherapy - 17 day(s) ago
Dose-escalated radiotherapy is increasingly used in the treatment of pancreatic cancer, however approaches to target delineation vary widely. We present the first North American cooperative group consensus contouring atlas for dose-escalated pancreatic cancer radiotherapy.
Source: www.redjournal.orgCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 202024 International Symposium of Gastrointestinal Oncology (ISGIO) - 2 month(s) ago
October 11-12, 2024
Source: www.gotoper.comCategories: General Medicine News, Hem/OncsTweet
First clinical PULSAR study is out! Congrats @MDohopolski, @TuDDan, @BobTimmermanMD & rest of UTSW CNS team! https://t.co/DJ9yJemn5K https://t.co/EfTnqXOMTU