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Mashup Score: 34The protein kinase C modulator bryostatin-1 therapeutically targets microglia to attenuate neuroinflammation and promote remyelination - 16 hour(s) ago
Protein kinase C modulation with bryostatin-1 enables innate immune cells in the central nervous system to promote myelin repair and regeneration.
Source: www.science.orgCategories: General Medicine News, NeurologyTweet
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Mashup Score: 16Lipids: Emerging Players of Microglial Biology - 23 day(s) ago
Lipids are crucial in mediating microglial metabolism and function. The microglial lipidome is vast and complex, with over 10,000 lipid species. We discuss key lipid classes and their roles in m…
Source: onlinelibrary.wiley.comCategories: General Medicine News, NeurologyTweet-
RT @LukensJohnR: Glia | Neurobiology Journal | Wiley Online Library https://t.co/GrJwnnSQLE
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Mashup Score: 1Imaging the Choroid Plexus - Niels Bergsland, Michael G. Dwyer, Robert Zivadinov, 2024 - 29 day(s) ago
The choroid plexus (CP), a highly vascularized structure within the ventricles of the brain, has come under increased scrutiny over the last several years as po…
Source: journals.sagepub.comCategories: General Medicine News, NeurologyTweet-
RT @Telencephale: https://t.co/gWQ3YwsXU1
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Mashup Score: 11
This comprehensive review aims to explore imaging outcome measures targeting compartmentalized inflammation in Phase 2 clinical trials for multiple sclerosis (M…
Source: journals.sagepub.comCategories: General Medicine News, NeurologyTweet-
Imaging biomarkers for compartmentalized inflammation will be critical for phase 2 studies of therapies targeting progressive MS. This is a nice, succinct review from @danielsaloreich summarizing current modalities https://t.co/tdXkKQqrUq
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Mashup Score: 7Discontinuation of First-Line Disease-Modifying Therapy in Patients With Stable Multiple Sclerosis - 30 day(s) ago
This randomized clinical trial investigates whether first-line disease-modifying therapy can be safely discontinued in patients with long-term stable multiple sclerosis.
Source: jamanetwork.comCategories: General Medicine News, NeurologyTweet-
Worth noting - in this population (median age around 54-55), discontinuation of first-line injectables, teriflunomide, and DMF after 5 years of stability led to substantially higher risk of disease activity. https://t.co/h2nB9jgeku
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Mashup Score: 6Myelitis Associated With Rheumatologic Disease - 2 month(s) ago
Podcast Episode · Neurology® Podcast · 2024-11-18 · 17m
Source: podcasts.apple.comCategories: General Medicine News, NeurologyTweet-
RT @jd_krett: Very informative interview highlighting our recent work on myelitis in rheumatologic disease https://t.co/0uZX7eYZim @ESotirc…
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Mashup Score: 34CNS macrophage contributions to myelin health - 2 month(s) ago
Myelin is the membrane surrounding neuronal axons in the central nervous system (CNS), produced by oligodendrocytes to provide insulation for electrical impulse conduction and trophic/metabolic suppo…
Source: onlinelibrary.wiley.comCategories: General Medicine News, NeurologyTweet-
RT @LukensJohnR: CNS macrophage contributions to myelin health https://t.co/oF7v6jmfl4 https://t.co/8u7ATerzro
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Mashup Score: 10
Background and ObjectivesPrevious reports of patients with myelitis associated with rheumatologic disease may have had unrecognized aquaporin-4 (AQP4)-IgG seropositive neuromyelitis optica spectrum disorder (NMOSD) or myelin oligodendrocyte glycoprotein (…
Source: www.neurology.orgCategories: General Medicine News, NeurologyTweet-
RT @jd_krett: Hot off the press -https://t.co/uwmWgJ9Er6
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Mashup Score: 32Multiple Sclerosis, Rituximab, Hypogammaglobulinemia, and Risk of Infections | Neurology Neuroimmunology & Neuroinflammation - 10 month(s) ago
Background and ObjectivesB-cell–depleting therapies increase the risk of infections and hypogammaglobulinemia. These relationships are poorly understood. The objectives of these analyses were to estimate how much of this rituximab-associated infection …
Source: www.neurology.orgCategories: General Medicine News, NeurologyTweet-
Multiple Sclerosis, Rituximab, Hypogammaglobulinemia, and Risk of Infections | Neurology Neuroimmunology & Neuroinflammation https://t.co/PiM7hVBb5S
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Mashup Score: 2
Acyl-coenzyme A (acyl-CoA) species are cofactors for numerous enzymes that acylate thousands of proteins. Here, we describe an enzyme that uses S-nitr…
Source: www.sciencedirect.comCategories: General Medicine News, NeurologyTweet-
Identification of a novel nitrosylase that uses SNO-CoA as substrate and regulates insulin signaling. Very nice story from Jonathan Stamler... https://t.co/hr6xq4ajUD
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Sharing our new work just released in @ScienceTM identifying PKC as a druggable target for modulating microglia function in order to enhance myelin repair. 🧵#remyelination #multiplesclerosis https://t.co/5x5H4ycYQE