During the winter months, an increased incidence of acute myocardial infarction (MI) and sudden cardiac death (SCD) has been documented after heavy snowfalls.1-3 For example, a large epidemiologic Canadian study reported that the quantity and duration of snowfall were associated with the subsequent risk of hospital admission or death due to MI.4 The risk appeared to be higher in men vs women the day after a snowfall. Accordingly, compared with 0 cm, 20 cm of snowfall was associated with an odds ratio (OR) of 1.16 for hospital admission due to MI for men but no increased risk for women (OR, 1.01).

To investigate the causal relationship between various lipid-modifying drugs and new-onset diabetes, as well as the mediators contributing to this relationship.

During the winter months, an increased incidence of acute myocardial infarction (MI) and sudden cardiac death (SCD) has been documented after heavy snowfalls.1-3 For example, a large epidemiologic Canadian study reported that the quantity and duration of snowfall were associated with the subsequent risk of hospital admission or death due to MI.4 The risk appeared to be higher in men vs women the day after a snowfall. Accordingly, compared with 0 cm, 20 cm of snowfall was associated with an odds ratio (OR) of 1.16 for hospital admission due to MI for men but no increased risk for women (OR, 1.01).

A 65-year-old woman with hypertension, hyperlipidemia, and occasional anxiety (untreated) presents to her primary care provider (PCP) with direct-to-consumer genetic test (DTC-GT) results. She is status post acute coronary syndrome with percutaneous coronary intervention 2 weeks ago. Her prescription medications include aspirin 81 mg daily, metoprolol 50 mg twice daily, clopidogrel 75 mg daily, simvastatin 20 mg daily, and lisinopril 10 mg daily. For her birthday, her daughter gave her a DTC-GT kit.

A 79-year-old woman presented to the emergency department with diarrhea, nausea, and poor oral intake for 1 week. Her medical history was notable for nonischemic cardiomyopathy, stage 4 chronic kidney disease (CKD) secondary to cardiorenal syndrome and a previous episode of severe acute kidney injury (AKI), and suspected proximal renal tubular acidosis 2 years ago secondary to previous chemotherapy for follicular lymphoma. She had a known history of chronic diarrhea that was attributed to small intestinal bacterial overgrowth (SIBO).