To evaluate sex-associated differences in the short- and long-term outcomes of patients with hypertrophic cardiomyopathy (HCM) undergoing septal myectomy and alcohol septal ablation.

A well-meaning colleague jokingly asked, “They let you wear your hair like that?” I paused and quickly responded, “Who would tell me to do anything with my hair?” (A.J.M.). I suddenly realized my privilege, not a common occurrence as a Black male from Baltimore City. Who would make the presumption of suggesting I change my appearance to conform to the norm? I thought of prior conversations with mentees who planned to cut their natural hair (ie, not altered by chemical products such as chemical straighteners/relaxers; eg, braids, Afros) and adopt commonly accepted styles (ie, short hair cuts, chemically straightened hair) before medical school and residency interviews.

An adult woman with a history of melanoma, basal cell carcinoma (BCC), and squamous cell carcinoma presented for her yearly skin evaluation. Examination showed an approximately 1-cm, shiny, pink, nodular-lobulated lesion with nonarborizing telangiectasias involving the upper chest near the neck (Figure 1). Because the clinical morphology was concerning for a BCC, shave biopsy followed by electrodessication and curettage was performed. Histologic examination revealed a well-demarcated mid to deep dermal neoplasm composed of solid nodules and small nests of epithelial cells without cytologic atypia or mitoses but exhibiting biphasic features consisting of polygonal cells with vesicular nuclei and eosinophilic cytoplasm as well as cells with clear cytoplasm, on a background of rich intratumoral vasculature and hyalinized stroma, characteristic of clear cell hidradenoma (Figure 2).

A woman in her 60s presented with a 7.8-cm small bowel mesenteric mass with associated lymphadenopathy (Figure 1). Histologic sections of the small bowel mesenteric mass show a dense infiltrate of lymphoid cells in a nodular distribution. The abnormal lymphoid cells are predominantly small, consistent with centrocytes, with few larger centroblasts. Immunohistochemical studies show that the neoplastic cells are positive for CD20, CD10, BCL6, and BCL2 (Figure 2).

To execute a large-scale, decentralized, clinical-grade whole exome sequencing study, coined Tapestry, for clinical practice, research discovery, and genomic education.

Statins are the mainstay of cholesterol treatment to prevent atherosclerotic cardiovascular disease. However, significant barriers, including physician and patient factors, prevent the optimal use of this drug class. In this article, we provide 10 clear and simple tips for clinicians when prescribing statins. The tips are based on the current guidelines, an extensive review of the literature, and decades of clinical practice of the senior author. Within the tips, we discuss key components of the guidelines, assessing cardiovascular risk profiles, evaluating drug-drug interactions, addressing adverse effects, and developing treatment plans that include statins and nonstatins.

A 37-year-old man presented to the emergency department with constant bilateral chest tightness during the preceding 2 days and acute worsening overnight that caused him to wake from sleep. He also endorsed discomfort in the suprasternal notch with radiation between the shoulder blades. The pain was exacerbated by leaning forward but also present when lying flat on his back. He denied any history of preceding trauma. He did have a recent exposure to COVID-19 2 weeks before presentation, and his daughters had recently been diagnosed with hand-foot-and-mouth disease.

A woman in her 60s presented with a 7.8-cm small bowel mesenteric mass with associated lymphadenopathy (Figure 1). Histologic sections of the small bowel mesenteric mass show a dense infiltrate of lymphoid cells in a nodular distribution. The abnormal lymphoid cells are predominantly small, consistent with centrocytes, with few larger centroblasts. Immunohistochemical studies show that the neoplastic cells are positive for CD20, CD10, BCL6, and BCL2 (Figure 2).

Angina with no obstructive coronary arteries (ANOCA) is clinically challenging to diagnose and to manage.1 Cardiac perfusion positron emission tomography (PET) is a valuable tool not only for the detection of obstructive coronary artery disease but also for concurrent quantification of myocardial blood flow (MBF) for the noninvasive identification of coronary microvascular dysfunction (CMD).2 Reductions in absolute hyperemic MBF or coronary flow reserve (CFR) can be quantified noninvasively by PET or invasively with a Doppler flow wire.

Historically, research on pulmonary embolism (PE) management has focused on short-term outcomes, such as acute cardiovascular collapse, change in right ventricular function, and in-hospital mortality. However, long-standing functional impairments from acute PE occur in up to half of all patients. This chronic syndrome has been termed the post-PE syndrome, which describes patients who have persistent or worsening symptoms, functional limitations, and cardiorespiratory impairment not explained by a comorbid condition.