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Mashup Score: 76Universal recording of immune cell interactions in vivo - 2 month(s) ago
Nature – A paper reports the development of a universal tool for studying cellular interactions in biological systems, and demonstrates its coupling with single-cell transcriptomics methods to…
Source: www.nature.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 76Universal recording of immune cell interactions in vivo - 2 month(s) ago
Nature – A paper reports the development of a universal tool for studying cellular interactions in biological systems, and demonstrates its coupling with single-cell transcriptomics methods to…
Source: www.nature.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 2Immunomodulation and immunopharmacology in heart failure - Nature Reviews Cardiology - 4 month(s) ago
In this Review, the authors discuss the clinical and experimental data on immunomodulatory effects of evidence-based treatments for heart failure and their primary mechanisms of action, and highlight potential therapeutic targets and opportunities for the development and application of novel immunomodulatory treatments for heart failure.
Source: www.nature.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 1Emerging Roles for Dendritic Cells in Heart Failure - 7 month(s) ago
The field of cardio-immunology has emerged from discoveries that define roles for innate and adaptive immune responses associated with myocardial inflammation and heart failure. Dendritic cells (DCs) comprise an important cellular compartment that contributes to systemic immune surveillance at the junction of innate and adaptive immunity. Once described as a singular immune subset, we now appreciate that DCs consist of a heterogeneous pool of subpopulations, each with distinct effector functions that can uniquely regulate the acute and chronic inflammatory response. Nevertheless, the cardiovascular-specific context involving DCs in negotiating the biological response to myocardial injury is not well understood. Herein, we review our current understanding of the role of DCs in cardiac inflammation and heart failure, including gaps in knowledge and clinical relevance.
Source: www.mdpi.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 1Transcriptomic Profiling Identifies Ferroptosis-Related Gene Signatures in Ischemic Muscle Satellite Cells Affected by Peripheral Artery Disease - 8 month(s) ago
BACKGROUND: We hypothesized that transcriptomic profiling of muscle satellite cells in peripheral artery disease (PAD) would identify damage-related pathways contributing to skeletal muscle myopathy.
Source: www.ahajournals.orgCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 21Spatially resolved multiomics of human cardiac niches - Nature - 10 month(s) ago
Single-cell and spatial transcriptomic analysis of eight human heartĀ tissues reveals theĀ cellular profiles and tissue architecture of niches including the cardiac conduction system, and a new tool, drug2cell, identifies drug target expression.
Source: NatureCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 73Self-extinguishing relay waves enable homeostatic control of human neutrophil swarming - 11 month(s) ago
Neutrophils exhibit self-amplified swarming to sites of injury and infection. How swarming is controlled to ensure the proper level of neutrophil recruitment is unknown. Using an ex vivo model of infection, we find that human neutrophils use active relay to generate multiple pulsatile waves of swarming signals. Unlike classic active relay systems such as action potentials, neutrophil swarming…
Source: bioRxivCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 5An atlas of genetic scores to predict multi-omic traits - Nature - 1 year(s) ago
A machineĀ learning approach is used to analyse multi-omics (proteomics, metabolomics and transcriptomics) data, producing genetic scores for more than 17,000 biomolecular traits in human blood, and identifying possible associations with disease.
Source: NatureCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 7
Among patients receiving contemporary statins, inflammation assessed by high-sensitivity CRP was a stronger predictor for risk of future cardiovascular events and death than cholesterol assessed by LDLC. These data have implications for the selection of adjunctive treatments beyond statin therapy and suggest that combined use of aggressive lipid-lowering and inflammation-inhibiting therapies…
Source: The LancetCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 3
Atherosclerosis is a lipid-driven chronic inflammatory disease; however, whether it can be classified as an autoimmune disease remains unclear. In this study, we applied single-cell T cell receptor seqencing (scTCR-seq) on human carotid artery plaques and matched peripheral blood mononuclear cell samples to assess the extent of TCR clonality and antigen-specific activation within the various T…
Source: www.nature.comCategories: Cardiologists, Latest HeadlinesTweet
RT @Nature: Nature research paper: Universal recording of immune cell interactions in vivo https://t.co/XVibs39M3W