-
Mashup Score: 18Heart Failure, Investigator-Reported Sleep Apnea and Dapagliflozin: A Patient-Level Pooled Meta-Analysis of DAPA-HF and DELIVER - 9 month(s) ago
Sleep-disordered breathing is a spectrum of sleep-related conditions; the 2 major types are obstructive sleep apnea and central sleep apnea.1–4 The former is characterized by a partial or complete obstruction of the upper airway during sleep and the latter by abnormalities in the brainstem respiratory centers, with a periodic reduction or cessation of respiratory effort without prominent airway collapse.1–4 Although central sleep apnea is rare in the general population, obstructive sleep apnea may afflict as many as 1 in 7 individuals in the world, although it is largely undiagnosed.
Source: onlinejcf.comCategories: General Medicine News, Partners & KOLsTweet
-
Mashup Score: 18Early Initiation of Sacubitril/Valsartan in Patients With Acute Heart Failure and Renal Dysfunction: An Analysis of the TRANSITION Study - 9 month(s) ago
Patients with comorbid heart failure (HF) and renal dysfunction (RD) have a worse prognosis than HF patients without RD, with higher rates of hospitalization, mortality, and morbidity.1 One of the additional challenges of management of patients with acute HF is the higher prevalence of RD (53%) compared with those with chronic HF (42%).2 Not only are patients with both HF and RD at a higher risk of adverse outcomes during the vulnerable postdischarge phase after acute decompensated HF (ADHF) episodes, but HF treatment initiation and up-titration can be more challenging owing to differences in HF drugs’ pharmacokinetics and pharmacodynamics.
Source: onlinejcf.comCategories: General Medicine News, Partners & KOLsTweet-
More data showing that #GDMTworks! Early use of sacubitril/valsartan in ADHF & renal dysfunction led to early & significant improvements in eGFR. Initiation and up-titration of ARNI early after ADHF are feasible and beneficial. 🔗 https://t.co/rZbgOsuaNU https://t.co/BHPSc9LVw7
-
-
Mashup Score: 18Heart Failure in Latin American Women: A Call for Action - 9 month(s) ago
Latin America (LATAM), defined as the region of the Americas where Romance (Latin-derived) languages, such as Spanish, Portuguese and French, are spoken, is composed of 33 countries, stretching from Mexico, Central America and the Caribbean to Chile, the farthest South American territory. Encompassing 8.3% of the world’s population (more than 670 million inhabitants, median age 31 years), 335 million women live in the various nations of this subcontinent, most of whom are categorized as having low or middle incomes.
Source: onlinejcf.comCategories: General Medicine News, Partners & KOLsTweet-
Change is needed to improve care of #Latinx ♀️ living with HF, by focusing on 👥 Social determinants of health in LATAM 🫀 Specific HF etiologies 🧬 Influence of genetics 🌡️ Particular clinical manifestations This amazing perspective piece is out now: 🔗 https://t.co/TzgQHy8XgB https://t.co/e07Di75AKC
-
-
Mashup Score: 37Cognitive Impairment in Heart Failure: A Heart Failure Society of America Scientific Statement - 9 month(s) ago
Cognitive impairment is common among adults with heart failure (HF), as both diseases are strongly related to advancing age and multimorbidity (including both cardiovascular and noncardiovascular conditions). Moreover, HF itself can contribute to alterations in the brain. Cognition is critical for a myriad of self-care activities that are necessary to manage HF, and it also has a major impact on prognosis; consequently, cognitive impairment has important implications for self-care, medication management, function and independence, and life expectancy.
Source: onlinejcf.comCategories: General Medicine News, Partners & KOLsTweet-
🚨🫀Out now in #JCF! A must-read @HFSA Scientific Statement on Cognitive Impairment in HF – The definitive guide to clinicians caring for the increasingly complex & growing sub-pop of aging pts with HF & impaired cognition. 🔗 https://t.co/blkFrrLTqm https://t.co/5eyawLgzRB
-
-
Mashup Score: 37Cognitive Impairment in Heart Failure: A Heart Failure Society of America Scientific Statement - 9 month(s) ago
Cognitive impairment is common among adults with heart failure (HF), as both diseases are strongly related to advancing age and multimorbidity (including both cardiovascular and noncardiovascular conditions). Moreover, HF itself can contribute to alterations in the brain. Cognition is critical for a myriad of self-care activities that are necessary to manage HF, and it also has a major impact on prognosis; consequently, cognitive impairment has important implications for self-care, medication management, function and independence, and life expectancy.
Source: onlinejcf.comCategories: General Medicine News, Partners & KOLsTweet-
🚨🫀Out now in #JCF! A must-read @HFSA Scientific Statement on Cognitive Impairment in HF – The definitive guide to clinicians caring for the increasingly complex & growing sub-pop of aging pts with HF & impaired cognition. 🔗 https://t.co/blkFrrLTqm https://t.co/5eyawLgzRB
-
-
Mashup Score: 32Cognitive Impairment in Heart Failure: A Heart Failure Society of America Scientific Statement - 9 month(s) ago
Cognitive impairment is common among adults with heart failure (HF), as both diseases are strongly related to advancing age and multimorbidity (including both cardiovascular and noncardiovascular conditions). Moreover, HF itself can contribute to alterations in the brain. Cognition is critical for a myriad of self-care activities that are necessary to manage HF, and it also has a major impact on prognosis; consequently, cognitive impairment has important implications for self-care, medication management, function and independence, and life expectancy.
Source: onlinejcf.comCategories: General Medicine News, Partners & KOLsTweet-
🚨🫀Out now in #JCF! A must-read @HFSA Scientific Statement on Cognitive Impairment in HF – The definitive guide to clinicians caring for the increasingly complex & growing sub-pop of aging pts with HF & impaired cognition. 🔗 https://t.co/blkFrrLTqm https://t.co/5eyawLgzRB
-
-
Mashup Score: 54Unmasking HFpEF with Artificial Intelligence: A Disruptive Opportunity for Disease Detection - 10 month(s) ago
Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent clinical syndrome that accounts for the majority of heart failure cases around the world. The prevalence of HFpEF has previously been reported to be between 1-5.5% of the general population1. However, this may be underestimated, given that diagnosis remains challenging, owing to a multitude of different etiologies and presentations that can be attributed to HFpEF2. With newly available therapies, making an earlier diagnosis of HFpEF has the potential to significantly change the trajectory of a patient’s disease course.
Source: onlinejcf.comCategories: General Medicine News, Partners & KOLsTweet-
🤖🫀 Can #AI detect HFpEF? In this #JCF Ignite article in press, @akarnikmd @maddiejane25 @AkhilNarangMD present their real-world experience of using AI to screen for HFpEF with #EchoFirst data. #THT2024 🔗https://t.co/rCZ6MyEjKW https://t.co/Zi0wUJmkaC
-
-
Mashup Score: 22The Ideal Heart Rate for Heart Failure and Ejection Fraction > 40%: Both Myth and Magic? - 10 month(s) ago
Patients with heart failure and an ejection fraction (EF) >40% do not have a single disease.1 Patients with an EF of >40 to <60% (HFmrEF) probably have a mild form of heart failure and a reduced EF (HFrEF), with a shift in the left ventricular (LV) end-diastolic pressure-volume relationship to the right, reflecting an increase in ventricular capacitance. In contrast, patients with an EF ≥60% (heart failure with a normal EF, HFnEF) have a shift in the end-diastolic pressure (LVEDP)-volume relationship upwards and to the left, indicative of a LV that responds to inflows with a disproportionate increase in LVEDP.
Source: onlinejcf.comCategories: General Medicine News, Partners & KOLsTweet-
🫀 Are pacemakers the answer for ideal HR in HFpEF? Dr. Milton Packer delves into the RAPID-HF & myPACE trials and suggests beta-blocker withdrawal in lieu of mechanical pacing for patients with HFpEF. #THT2024 #JCF 🔗https://t.co/za3G0eBTt1 https://t.co/x2vveYjhII
-
-
Mashup Score: 43Going with the Flow: Device therapy for Heart Failure Complicated by Cardiorenal Syndrome - 10 month(s) ago
Cardiorenal syndrome (CRS) affects up to 40% of patients admitted with acute decompensated heart failure (ADHF) [1]. Although the precise mechanisms driving ADHF-CRS at the neurohormonal and cellular levels have not been fully elucidated, is it clear that the syndrome results from complex, multifactorial pathophysiologies, inclusive of reciprocal and unfavorable hemodynamic interactions between the heart and kidneys,[2] along with neurohormonal activation and fibrotic structural changes that contribute to progressive cardio-renal dysfunction and congestion.
Source: onlinejcf.comCategories: General Medicine News, Partners & KOLsTweet-
“Pushing & pulling” to fight CRS in acute #HeartFailure. 🫀 In this #JCFIgnite article in press, @LAuroraMD @gfgrafton @preventfailure discuss the latest in med devices to ⬆️ renal perfusion or ⬇️ venous hypertension. 🥊 #THT2024 🔗 https://t.co/P6B0K3iIJz https://t.co/Z2CENkBBSy
-
-
Mashup Score: 20Early Experience With Devices That Reduce Kidney Vascular Afterload From The Veins - 10 month(s) ago
Worsening renal failure due to cardiorenal syndrome (CRS) is noted in nearly one-third of acute decompensated heart failure (ADHF) admissions (1). The pathophysiology of CRS in patients with ADHF is a self-perpetuating cycle attributed to both poor renal artery perfusion, or “preload,” as well as increased renal venous congestion, or “afterload.” The etiology of reduced renal artery preload is multifactorial. Low cardiac output, activation of the renin-angiotensin-aldosterone system, and hypotension, lead to a compensatory vasoconstriction of the renal artery and glomerular afferent arterioles as the kidney attempts to maintain a constant glomerular filtration rate (GFR) (2).
Source: onlinejcf.comCategories: General Medicine News, Partners & KOLsTweet-
⬆️ Kidney vascular congestion can worsen diuretic resistance in ADHF. @SpringMD @UlrichJordeMD explore this & device-based therapies for patients with renal venous congestion in the latest #JCF Ignite article in press. #THT2024 🔗 https://t.co/fFYB2V3aVy https://t.co/qDCyoHSQa9
-
🔥New science alert! In this patient-level meta-analysis of DAPA-HF & DELIVER, investigators found that sleep apnea was associated with worsening HF. Dapagliflozin reduced the risk of clinical outcomes & improved QoL. #GDMTworks 🔗 https://t.co/IzfSqrYA3A https://t.co/SEGcG1hJHS